The Study Of Pulse Pressure And Target Organs Damage In Essential Hypertensive Patients

The study of pulse pressure and target organs damage in essential hypertensive patientsObjective: To investigate the relationship of pulse pressure (PP) to target organs damage in essential hypertensive patients.Methods: 696 cases of untreated primary hypertensive patients (male 387 N female 309 year from 38 to 86) were divided into two groups according to the level of mean arterial pressure (< 107 and ^lOTmmHg). Each group was further divided into four subgroups according to the level of pulse pressure (^60, 61~80, 81 ~ 100 and >100mmHg). Supine blood pressure was measured in the right arm with the use of a manual sphygmomanometer. LVMI, EF and FS were measured and calculated by transthoracic echocardiography. BMI, SBA, the serum level of glucose, lipids, BUN, Cr, UA, CCr, LVMI, EF, FS and the incidence of cardiavascular events were compared among these subgroups. Results: (1) The course of diseases, the number of drinkers,and smokers, BMI, SBA, the level of glucose, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoptotein (LDL) was not significant difference among the subgroups in the patients with essential hypertension ( all P >0.05). (2) The age of patients, BUN, Cr, UA, SBP, LVMI was positively correlated to PP (r=0.75 , 0.60 , 0.70 , 0.48 , 0.59, 0.56 respectively, all P<0.05), however the level of CCr, DBP, and FS, EF was negatively correlated to PP (r=-0.68, -0.52, -0.49 , -0.51 respectively, all P<0.05). (3) The coronary heart disease, left ventricular hypertrophy, heart failure and cerebral complication was correlated to the age of patients, SBP, DBP and PP (all P <0.05), however,PP plays a more important role.Conculsions The target organs damage in the primary hypensivepatients is correlated to the age of patients, SBP, DBP and PP. However,PP plays a more important role than other three factors in thepathogenesis of the target organs complication.