The Study Of FKZXKL In Pharmacology And Toxicology

FKZXKL is a being developed pharmacon,which is based in herb mixture .whose efficiency has been comfirmed clinically.This study researched the main pharmacology and mechanism from blood coagulability and fibrinolysis,uterus activity,sexual organ and hormone and anti-inflammatory and antalgesic.The main results as follows: 1. FKZXKL (5 g kg拁 10 g kg1.. 20g kg~1) could markedly shorten BTand CT in mouse; FKZXKL(16 g kg1 )could significantly shorten PT and content of FDP. 2. FKZXKL (8 g 慿g?. 16g kg? could markedly increase content of FSI-I.. LI-I and E~ in rats. 3. FKZXKL (25g kg?. 5g kg1.. lOg?kg? by duodenum could significantly strengthen activity altitude of uterus in vive; FKZXKL (0.05 g.. 0.1 g.. 0.2 g) could significantly strengthen activity altitude and frequency of uterus in vitro 4. FKZXKL (20 g?kg? could inhibite dimethylbenzene-induced swelling degree of ear in mouse .FKZXKL (16g kg? could inhibite turpentine-induced proliferation in rats. 5. FKZXKL (8 g kg?16 g kg? could markedly increase content of PGE, in blood and decrease that in uterus in rats 6. LD50 of FKZXKL material was 37 89 g kg? 95% confidence interval was34 68- 41.40 g kg?by ip in mouse Maximal dose of per day was 105 g kg~?and that of FKZXKL was 78.75 g kg?by ig. 7. FKZXKL hadn抰 markedly effect on general condition and urine andmorphology of organs .FKZXKLcouId shorten CT and decrease number of WBC .. ALT.. TP.. T-CHO by ig, but could recover after stopping for two weeks.FKZXKL could increase 5 coefficient of ovary and uterus,but decrease that of spermary and couldn抰 recover after stopping for two weeks. Conclusion:FKZXKL has actions of anti-inflammatory, strenthening coagulatory,modulating sexual hormone and strengthening activity of uterus ,and could markedly change secretion of PGs The results of toxicolgy suggested FKZXI(L is efficient and safe.