| Objective: In normal adults, to observe the changes of blood pressure (BP), heart rate (HR), double product (DP), and heart rate variability (HRV) during the course of sexual activity; to examine plasma level of thromboxane B2 (TXB2) , 6-Keto-Prostaglandin F1a (6-K-PGF1a) , endothelin (ET) after sexual activity; and to evaluate if sexual activity is one of the cardiovascular risk factors.Methods: Ninety-nine adult volunteers were recruited at the beginning of the study. Volunteers meeting the inclusion criteria and having complete data were employed as research subjects. Forty-nine subjects (22 males, aged 40.6±7.8 years; 27 females, aged 40.3±7.8 years) underwent simultaneous ambulatory monitoring of BP and HR. Card(x)plore monitor (made in Meditech company, Hungary) was employed for 24 hours monitoring. Intercourse was finished under the usual conditions with missionary position during the course of monitoring. Subjects were requested to measure the BP at the beginning of each period and 3 times after orgasm in every 10 minutes interval. There were 8 time points for measurements from baseline to 1 hour after orgasm in the study. The data of BP, HR, DP, SDNN and LF/HF were obtained by a special software. Forty-three subjects (22 males, aged 39.9±6.0 years; 21 females, aged 37.8±7.2 years) were asked to participate the experimental study. Intercourse was finished with missionary position at their home. Blood samples were collected from median cubital vein at the spot. The time periods were baseline condition and 3 time periods after orgasm. Plasma TXB2, 6-K-PGF1a and ET concentrations were measured by radioimmunoassay. The data were analyzed with the paired t test and the differences between groups were analyzed with the t test. Statistical significance was set at P<0.05.Results: In both groups, the peak value of BP did not appear at the beginning of orgasm, but appeared at the beginning of excitement, and dropped to baseline level at 10 min after orgasm (male 141.41/91.05mmHg vs 120.14/72.86mmHg, female 121.67/77.37mmHg vs 109.37/67.19mmHg). The peak value of HR appeared at the beginning of orgasm, and dropped to baseline level 10-20 min after orgasm (male 96.36bpm vs 75.41bpm, female 90.19bpm vs 71.44bpm). DP of two groups elevated at the beginning of excitement and orgasm, decreased to baseline level 10 min after orgasm (male 12964.27mmHg·bpm vs 9134.09mmHg·bpm, female 11009.44mmHg·bpm vs 7841.30mmHg·bpm). SDNN and LF/HF were not significantly changed during sexual activity. Plasma concentrations of TXB2 and ET decreased, whereas 6-K-PGF1a levels increased after sexual activity in both groups. The minimum value of TXB2 (462.07pg/ml... |
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