| Alzheimef s disease, alias senile dementia, is a kind of primary retrogression of brain tissue which happens in the elderly people. Its incidence increases in old age. The epiderniological survey in foreign countries indicates that its incidence was58%~4 5.3% among people elder 65. In American AD is the forth-main pathogenic factory next to heart disease, cancer, and apoplexia. In China, the epidemiological survey today shows that the accurance of AD is similar to that in developed countries. The pathology of All s are as follows: 1 general atrophy of brain and the loss of neuron; 2 senile plaque; 3 nerve fiber tangling. Aging heredity and genic mutation are the definite main pathogenic factors; in addition the decrease of neurotransmitter, inflammation, stress, etc are the possible pathogenic factors. There is no effective treatment method for AD known to man today, and the treatment is mainly according to symptom and pathogeny. 1CM has a potential ability to AD. According to the theory of TCM the main pathogeny and pathogene are the followings: I kidney deficiency failing to produce, marrow is the basic reason of AD; 2 disharmony of zangfu, qi and blood deficiency, failing to nourish brain is the necessary condition of AD抯 formation; 3 brain deficiency and phlem and stagnation are key; 4 Atrophy of brain and disfunction of spirit are the symptoms in the end. Kidney stores essence, which produces marrow, and brain is the sea of marrow This special idea in 1CM theory is the basis of the principle, strengthen Kidney and increase intelligence, which effectively direct the clinic work. Bushenyizhifang is created by Professor Lai Shilong. The main components are ginseng the root bank of the tree peony, The tuber of multiflower, knotweed, uatrimony vine and others. It has the function of strengthen yin and yang, nourish qi and move blood and inducing resuscitation. Previous experiment has proved that it has an obvious effect on senile rats. On clinic it also shows some effect of improving the symptoms of patients who suffered from senile dementia. Long-term potentiation (LIP), a model of synaptic plasticity, is an index of neuron action during the course of remembering and shows the course of study and memory on neuron synaptic level. The better the study and memory ability is, the more obvious the LIP is. The worse the ability is, the less obvious the LIP is. And it can抰 even be induced Out. This experiment directed by the 1CM theory. Strengthen kidney and increase intelligence focuses on the laboratory study of the treatment of Bushenyizhifang on laboratory dementia rats and the way it works. In order to evaluate the effect of Bushenyizhifang. The LIP variations of induced potential of the rats, in different groups through the rat hippocampal slice technique 4 and Morris Water Maze (MWM). Furthermore the way it works wasalso discussed. 80 healthy SD rats provided by Experiment Animal Center of Guangzhou University of TCM were used in this experiment. 50% male, 50% female. They were divided into three groups: 10 of younger group, 10 of senile groups, and 60 of animal model group. The method of making animal model: lntraperitoned injection of D-glucose was used to the rats of senile group and model group, the does was48mg/kg/d, once a day, six weeks. From the 43day Ibotenic acid was injected to Meynert, 2 LL t per side to the rats of model group. Two weeks later the alive were divided into high-dose group, low-dose group, huperzine-A group and model group randomly. Fed with herbs, med...
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