Design And Synthesis Of Ethyl 5 - Hydroxy - 6 - Bromo - 1H - Indole - 3 - Carboxylic Acid Ethyl Esters

In this paper, the influenza virus and the biological characteristics of influenza virus were described briefly, and research progress of varieties of anti-influenza agents was described in detail. On the basis of our previous research work, we focus our attention on the design and sunthesis of a series of new ethyl 5-hydroxy-1H-indole-3-carboxylate derivatives.We took Abidol, a new antiviral agent, as the lead compound, and preserved the indole scaffold, 5-hydroxy and 3-ethoxycarbonyl, and modified the substituents at 1-position, 2-position, and 4-position on the indole ring. With ethyl acetoacetate as starting material, followed by condensation, Nenitzescu cyclizition, acetylation, bromonation, etherification, Mannich reaction and oxidation, totally 21 target compounds of ethyl 5-hydroxy -1H-indole-3-carboxylates that never reported in literatures were designed and synthesized, and their structures were confirmed by ~1-NMR and MS.Their antivirul activities are being in progress.