Expression And Significance Of Apoptosis - Related Proteins In Lichen Planus

Objective The objective of this study was to investigate the expression and significance of nuclear factor kappa B(nuclear factor kappa B, NF- κ B) and apoptosis-inducing factor(apoptosis-inducing factor, AIF) in lichen planus(LP).Methods Immunohistochemistry and TUNEL(Terminal deoxynucleotidyl transferase-mediated d UTP Nike End Labeling) was used to detect the integrated optical density and apoptosis index of NF- κ B and AIF in paraffin-embedded samples of lichen planus(n=25) and normal skin samples(n=25).Results The results show that the integrated optical density of NF- κ B and AIF in LP were higher than that in the control group(t=3.14 and 4.09, P<0.01); Keratinocyte apoptosis index in lichen planus was significantly higher than that in the control group. Statistically significant differences between the two groups(t=4.97,P<0.01). There was no correlation between the expression intensity of NF- κ B and its own apoptosis index(r=0.13,P>0.05), The expression intensity AIF in lichen planus group was positively correlated with its own apoptosis index(r=0.64,P<0.01).Conclusions The expression of AIF in the lesions of lichen planus may be involved in the cell apoptosis excitement of keratinocytes. NF- κ B may be closely associated with the inflammatory response in lichen planus.