Study On The Clinical Relevance Of Recurrent Children With Acute Lymphocytic Leukemia In Low Risk Group

Objective: This paper aims to analyze the chemotherapy data of childhood acute lymphoblastic leukemia(ALL) in low-risk group in the Affiliated Hospital of Qingdao University and to explore the relevant factors of recurrence in the low-risk children group.Methods: Selecting cases were diagnosed as B-type low-risk group from May 1, 2005 to April 30, 2009 in pediatric hematology of our hospital through retrospective study and were treated with the scheme of Shanghai Children’s Medical Centre-Acutue Lymphoblastic Leukemia-2005. In the end of September 30, 2011, the study has excluded the abandoned and lost follow-up cases and made a statistic analysis with the rest of data. The study contains 45 cases diagnosed as B-type low-risk ALL, among of which, recurrence group was consisted of 6 cases, 3 male cases and 3 female cases respectively. In the rest of 39 cases, 6cases with the same gender and similar body surface areas were selected as control group to collect and process clinical data. Independent sample T-test was carried out to analyze the differences among the mean value of test samples. All the data in the study are processed by SPSS17.0.Results: 1. The comparison of clinical data between recurrence group and control group before treatment: there were no sharp differences(P value > 0.05) in general condition of attack, fusion gen and chromosome. 2. Treatment Condition:(1) M period: The treatment duration of recurrence group was much longer(p=0.047).(2)Infection frequency: recurrence group has increased rapidly(p=0.049) in Cs1, while, duration of anti-infection therapy was no sharp differences in the first three phases(P value > 0.05). 3. The number of lumber punctuate and blood infusion: there were also no obvious differences in the number of lumber punctuate, infusion of red blood cells and platelets(P value > 0.05). 4. The utilization of chemotherapy drugs: In the first three months, the intensity utilization of cytarabine, 6-mercaptopurine and methotrexate of recurrence group was much lower than the intensity of that of control group(P value< 0.05).Conclusion: 1. As for treatment duration in M period, the recurrence group is much longer than control group, which indicates the extension of treatment duration in M would cause recurrence. 2. The time of infection frequency of recurrence group is much more than that of control group which signifies that increasing infection would cause recurrence.3.Lower intensity utilization of cytarabine, 6-mercaptopurine and methotrexate is the root of recurrence. 4. Clinical data, the number of lumber punctuate and blood infusion have no obvious influence on recurrence. 5. The scheme of individual chemotherapy, proper nursing care to avoid infection and completion of chemotherapy as planned play a vital role in reducing the chance of recurrence. 6 The study lacks enough sample which need further exploration.