A Review Of The Effects Of Hypothyroidism On Early Spontaneous Abortion

Early threatened miscarriage refers to in the early 12 weeks during pregnancy, vaginal punctuate a little blood, the waist is sour and discomfortable, having the lower abdomen pain, quicken frequently, but the size is consistent in pregnancy, and the cervix does not open,pregnancy is likely to be continued.The synthesis, secretion, metabolism and regulation of thyroid hormones duringpregnancy are all changed with gestational age as well as thyroid immunity. As the research continues, in the present review, we discuss the various effects of hypothyroidism during pregnancy of note, even subclinical hypothyroidism can adversely mpact pregnancy.Such asgestational hypertension, placental abruption,premature delivery, deformed fetus and postpartum heorrhage. And one of the most serious complication is early threatened miscarriage.Therefore,the early diagnosis and treatment of hypothyroidism during the gestational period is especially important.At present,thyrotrophic-stimulating hormone(TSH) is used as the first-line marker for diagnosis of thyroid disease in pregnancy.A TSH level of 2.5 mIU/L is recommended as an appropriate conservative upper limit for the first trimester of pregnancy.Chinese medicine has no definition of Early threatened miscarriage with hypothyroidism, but it could fit with "fetal leakage","quickened uneasy","recurrent miscarriage" according to the clinical characters and features.The major dialectics of Early threatened miscarriage with hypothyroidism is kidney deficiency and qi-blood deficiency.Chinese medicine treatment methods of replenishing Qi toinvigorate the spleen,tonifying kidney and warming yang can adjust the balance between Qi and blood based on its pathogenesis. In addition to the treatment of Chinese medicine, levothyroxine treatment is one kind of a conventional treatment of Western medicine so as to improve the endocrine metabolic state and lower the level of serum TSH to achieve final purpose to reduce the abortion.On the basis of literature, combination of Chinese traditional and Western medicine on Early threatened miscarriage with hypothyroidism is more better than TCM or western medicine by oneself.Combining TCM and western medicine is the developmental tendency in treating Early threatened miscarriage with hypothyroidismin part to make up for the simple use of western medicine therapy oneness and limitation, and also reduce the pure application of western medicine treatment some side effects, the patients of symptoms and signs also has the obvious improvement, good use of their advantages, shows its unique advantages and good development prospect.