| Objective To study the efficacy and safety of YiShenGuKang Ointment on relieving the somatic cancer pain of kidney deficiency and blood stasis pattern.Methods In this study, a randomized, controlled prospective clinical trial was designed. A total number of 69 patients with moderate to severe pain were randomly divided into treatment group (N= 39) and control group (N= 34),both of which were given opioids analgesic therapy. On this basis, the treatment group were externally treated with YiShenGuKang Ointment. The therapeutic course lasted for 10 days. Before and after the treatments, such indices as NRS pain scores, Karnofsky scores,grade in impact of pain measurement and so on were compared with each other, and their clinical therapeutic results were evaluated.Results Compared with the control group (total efficiency 84.3%, significant efficiency58.9%),the total efficiency of the treatment was 94.3%,and the significant efficiency was 85.6%,which shows significant difference between these two groups (P<0.05). After the treatment, the NRS pain scores decreased remarkably in the treatment group(betoretreatment:5.1+ 1.471, after treatment:1.86±1.700, P<0.05), so as to the grade in impact of pain measurement (before treatment:40.23±12.533,after treatment:23.77±12.386,P< 0.05),both of which show significant difference compared with the control group (P<0.05). Meanwhile, the Karnofsky scores, the frequency of breakthrough pain and so on were also statistically conducted.The mean occurrence of breakthrough pain of the treatment group was less than control group(0.77± 0.424VS1.22±0.726, P<0.01), and the Karnofsky scores were significantly better(70.00±15.339VS62.94±11.685,P<0.05). No adverse reaction like skin allergy was found during the treatment.Conclusion YiShenGuKang Ointment is effective in relieving the somatic cancer pain of patients with the kidney deficiency and blood stasis pattern,which can better improve the quality of life and deserve to be applied because of its safety. |
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