| Objective:Through research the relevance of traditional Chinese medicine treatment and survival time,to explore the effect of Chinese medicineon survival in patients withprimaryliver cancer,and do the subgroupresearch according to the tumor stage andgrade of liver function,physical status score,to sum up the clinical curative effect and the advantage of the characteristics of huatanjiedusanjie method in treatment of primary liver carcinoma,making it a suitable for clinical application of Chinese medicine treatmentof primaryliver cancer, to prolong the life of patients with primary liver cancer and improve thequality of life.Method:This research is a multi-center prospective cohort study design,in strict accordance with the inclusion criterialO2 cases were collected,in accordance with the exclusion of 5 cases,divided into group of qualifiedpatient with a total of 97 caseswith huatansanjie methodas exposure group,the exposure factors of a total of 50 cases,4 cases lost following up,the cases from Xiyuan Hospital;the non exposed group with treatment of Western medicineconsisted of 47 cases,3 cases lost following up,patients from the Army 309 Hospital.The follow up time was 31 months from June 1,2012 to January 1,2015.Observe the average survival time,median survival time and survival rate of the two queue,and tumor BCLC staging,UICC staging,liver function of child Pugh grading and ECOG performance status score were subgroups in comparison to explore the influence of huatanjiedusanjie method for primary hepatocellular carcinoma patients and summarize the efficacy and advantages.Results:1 The comparison of two column lifetime:The median survival time of exposed group was (269±125) days longer than non exposed group 23 days,for 1.5 years survival rate,the exposure group was 34%,the non exposed group was 23%.The effect of two column have the statistical significance,indicating that the huatanjiedusanjue method compared with the western medicine treatment can prolong the survival time of patients and improve the survival rate of patients.2 Comparison of survival of patients with retreatment and the first treatment:The median survival time of the patients with first treatment in the exposed group is longer for (462±103) than non exposed group 87 days; for 1 year half survival rate and exposure group was 44%, non exposed group was 27%, the difference in the curative effect without statistical significance. The median survival time of the patients with first treatment in the exposed group is longer for (458+54) than non exposed groups of 193 days; for 1 year half survival rate and exposure group was 38% and the non exposure group was 23%, the difference in the curative effect without statistical significance.3 The comparison of two column lifetime of different tumor staging:For BCLC staging,patients into groups was almost all the tumor stage C,the group from the study on patients with tumor stage C,as exposure group,the median survival time was (411±156) days longer than non exposed group 123 days,for the 1.5 years survival rate,the exposed group was 43%,the non exposed group was 28%.The two column curative effect was difference in statistics.For UICC staging, patients into groups for most of the stage III and IV, the group from the study on patients with tumor in stage III and IV patients and found that huatanjiedusanjie method for the patients with stage IV has more advantages,which can prolong the survival time of the patients and improve the survival rate,and there were statistical significance in the efficacy for pure western medicine treatment,for stage III patients with no statistically significant difference.As the results, for the stage III patients,the median survival time can not be obtained due to the censored rate of more than 50%,for the 1.5 years survival rate,the exposed group was 42% and the non exposed group was 28%;for stage IV patients,the median survival time of exposed group was (186±50) days longer than non exposed group 45 days.The 1.5 years survival rate of exposed group was 5% and there no patient lived 1.5 years in non exposure group,if the sample size was increased,this trend may be more obvious.4 The comparison of two column lifetime of different Child-Pugh classification of liver function staging:The huatanjiedusanjie method effect on the patients with liver function grade A has more advantages,which can prolong the survival time of the patients and improve the survival rate,and the effect of two column have the statistical significance.For patients of liver function grade B,the effect of two column have no statistically significant difference.As the results,for patients of liver function grade A,the median survival time was (505±325) days longer than non exposed group 231 days,for the 1.5 years survival rate,the exposed group was 49% and the non exposed group was 35%;for patients of liver function grade B,the median survival time was (200±55) days longer than non exposed group 31 days,for the 1.5 years survival rate,the exposed group was 34% and the non exposed group was 12%,if the increase in sample size,this effect of liver function grade B will be more obvious.5 The comparison of two column lifetime of different ECOG physical status:The most patients into groups was that the ECOG score was 1 and 2,the huatanjiedusanjie method effect on the patients whose ECOG score was 1 has more advantages,which can prolong the survival time of the patients and improve the survival rate,and the effect of two column have the statistical significance.For patients whose ECOG score was 2,the effect of two column have no statistically significant difference.As the results,for patients whose ECOG score was l,the median survival time can not be obtained due to the censored rate of more than 50%,for the 1.5 years survival rate,the exposed group was 59% and the non exposed group was 41%;for patients whose ECOG score was 2,the median survival time was (182±24) days longer than non exposed group 37 days,for the 1.5 years survival rate,the exposed group was 21% and the non exposed group was 9%,if the increase in sample size,this effect will be more obvious.Conclusion:Huatanjiedusanjie in prolonging the survival time of patients and improving survival rate of curative effect than pure western medicine treatment is more effective.BCLC staging of tumor was C stage, UICC stage for IV stage, liver function Child-Pugh grade for Grade A and ECOG score for 1 points of primary liver cancer patients would have more advantages. |
PDF Full Text Request