Synthesis And Study Of Multi-structure Compounds With 1, 2, 3-triazole

1H-1,2,3-triazole derivatives are one type of chemical compound that haves widely biological activities and extensive use to industry,agriculture and medicine and so on.Based on their vast foreground,the compounds are researched by more and more chemists,and many novel significant compounds were synthesized.Seeing that the above-mentioned,some new heterocyclic compounds which contain 1,2,3-triazole nucleus were synthesized and studied in this thesis.There are two major parts in this thesis:The first part is about literature review.The research status and development of the 1,3,4-thiadiazolo[3,2-a]pyrimidinone,pyrazole,pyridine,and KF-Al₂O₃ catalyzed machael reaction.The second part is about experiment sections.Major work is as follows:1.P₂O₅-HCOOH catalyzed Diversity-Oriented Synthesis of 2-(1-Aryl-5-methyl-1H-1,2,3-triazol-4-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives.2.Synthesis of 5-Aryl-4,5-dihydro-3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-1-(4-phenylthiazol-2-yl)pyrazoles.3.Chemical selective synthesis of 6-Alkoxy-4-aryl-2-(1-aryl-5-methyl-1H-1,2,3-tri azol-4-yl)-5-cyanopyridines and 2-amino-6-aryl-4-(1-aryl-5-methyl-1H-1,2,3-tri azol-4-yl)isophthalonitriles.4.KF-Al₂O₃ catalyzed conjugate hydrocyanation ofα,β-unsaturated ketones with malononitrile.