Stereoselective Synthesis Of ?-Glycosyl Azides By Ring-Opening Of 1,6-Anhydrosugars And Its Applied Research

A new direct and stereospecific synthesis of a-glycosyl azide is described. And we studied the application of a-glycosyl azide in "Click Chemistry" as well. There is three chapters in it.Chapter one mainly has two big parts. The first part mainly introduces the ?-glycosyl azide application in N-glycoconjugate. The seconde part describes the glycosyl azide various synthesis methods.Chapter two introduces the concrete methods used for the synthesis of carbohydrate azide. We are using TMSN3 as reagent in the acid in the presence of internally 1,6-anhydrosugars ring-open.Chapter three wrote our research on the application of the a-glycosyl azide by 1, 3-dipolar cycloaddition. Synthesized multiple alpha 1?2,1?3,1?4,1?6-N-glycosidic analogues, and provides a new way for the synthesis of oligosaccharides molecules.