Experimental Study On Ultrafiltration Of BSA And Membrane Separation Of Liensinine

The factors which affect the fouling degree of membrane and the flux decay rate during ultrafiltration processs were studied in this paper using BSA as model system and PEK-5000 and PES-10000 ultrafiltration membrane as test membranes. The result of experiments indicates that: with operation pressure increases, the fouling degree of membrane and the flux decay rate both increase; with operation temperature increases, the fouling degree of membrane and the flux decay rate both exist maximum point; when the pH value of the feed solution equals to the isoelectric point of BSA, the fouling degree of membrane and the flux decay rate both exhibit maximum value; with the concentration of BSA increases, the fouling degree of membrane and the flux decay rate both increase; with the flow rate of feed increases, the fouling degree of membrane and the flux decay rate both decrease.The steady state flux prediction of ultrafiltration has been hot issues in ultrafiltration theory. In this paper a model for calculating steady state flux of ultrafiltration is developed, which is based on filtration theory and combined with Einstein-Stokes' law and Happel's cell model. The ultrafiltration constant is introduced to this model, by which the steady ultrafiltration process can be divided into two types: in the presence of cake and in the absence of cake. The model proposed in this work is of full predictability, and no additional experiments in determination of the model parameters are needed. The error between calculating result and experiment result is in the range of 50% to 60%.The Shuxin－Jiangya is the second type new medicine of Traditional Chinese Medicine made in No 2 Pharmaceutical Factory of Da Ren Tang. The low efficiency between liensinine and chlorophyll separation severely hindered the economics in the production of Shuxin－Jiangya preparation. A combined technology is developed in this paper, which coupling degrease cotton adsorption with membrane separation. By this method, liensinine and chlorophyll with only little difference in the relative molecular weight can be separated effectively. The centrifugal,filtration and extraction of conventional process were replaced by degrease cotton adsorption,filtration and membrane, thus the operating time is shorten considerably. The experiment result showed that: the content of active components is increase from 75%to 85%. The appropriate technical parameters of our new technology were also investigated systematically, and different optimum conditions were found for different object functions.