An Exploratory Study Of A New Mode Of Opportunistic Screening In First-degree Relatives And Spouses Of Patients With Colorectal Neoplasms

Objective To explore the effectiveness of a new mode of opportunistic screening based on the combined detection of three methods in colorectal wards in the screening of firstdegree relatives and spouses of patients with colorectal tumors.Methods The Asia-Pacific colorectal screening(APCS)score,fecal immunochemical test(FIT)and multitarget stool DNA testing were used to detect first-degree relatives and spouses of colorectal cancer and advanced adenoma patients treated at the Department of Colorectal Surgery,Cancer Hospital,Chinese Academy of Medical Sciences from October 2019 to July 2021.Based on the test results,screening risk stratification and recommended colonoscopy classification for first-degree relatives and spoues were performed,and their colonoscopy compliance rate and lesion detection rate were analyzed.Results A total of 250 first-degree relatives and 206 spouses were included in the analysis.The colonoscopy compliance rate in first-degree relatives was 38.0%(95/250),and the detection rate of colonoscopy lesions in first-degree relatives was 9.5%(9/95);the colonoscopy compliance rate of category A recommended population was 78.9%(15/19),the lesion detection rate was 26.7%(4/15);the colonoscopy compliance rate of category B recommended population was 61.2%(30/49),and the lesion detection rate was 16.7%(5/30);the colonoscopy compliance rate of the category C recommended population was 27.5%(50/182),and the lesion detection rate was 0(0/50).The colonoscopy compliance rate in spouses was 29.6%(61/206),and the detection rate of colonoscopy lesions in spouses was 9.8%(6/61);the colonoscopy compliance rate of category A recommended population was 90.9%(10/11),the lesion detection rate was 30.0%(3/10);the colonoscopy compliance rate of category B recommended population was 53.5%(23/43),and the lesion detection rate was 8.7%(2/23);the colonoscopy compliance rate of the category C recommended population was 20.5%(23/112),and the lesion detection rate was 4.3%(1//23);the colonoscopy compliance rate of the category D recommended population was 12.5%(5/40),and the lesion detection rate was 0(0/5).Conclusion The combined use of the three screening methods can efficiently and accurately distinguish the screening risk of first-degree relatives and spouses.This program is an effective and feasible ward-based mode of opportunistic screening in first-degree relatives and spouses of patients with colorectal neoplasms.