| Objective:The research,based on the theory of " predisease treatment" in traditional Chinese medicine and the hypothesis of " liver failing to govern conveyance and dispersion accelerating brain ageing ",with the help of neuropsychological screens and neuroelectrophysiological technology,found out the sensitivity indicators of early cognitive decline of normal people with different levels of emotional regulation in ageing;and explored the effects of liver failing to govern conveyance and dispersion caused by long-term emotional stagnation and its neuro-electrophysiological mechanism,in order to provide theoretical and empirical evidence for early diagnosis,emotional etiology and pathogenesis,and early prevention and treatment from the liver of cognitive decline.Methods:The general situation questionnaire,the adult version of the Eysenck Personality Questionnaire and the Mini Mental State Examination scale were used to screen the research subjects who met the criteria of high and low neuroticism from the normal population as the long-term emotional stagnation group and the emotional well-being control group,respectively.the two groups of subjects were matched 1:1 according to the same gender,the same age(±3 years),and the same educational level,and each group of subjects was divided into 18-30 years old,30-45 years old and 45-65 years old according to the age distribution.Three age groups,with the same sex ratio among each age group,40 cases in each age group were included in each group,a total of 240 cases.The physical symptoms and emotional state of the liver were evaluated by Emotion Rating Scale for Ganzangxiang of Traditional Chinese Medicine(ERSG);the Montreal Cognitive Assessment(Mo CA)scale was used to detect the overall cognitive function and the level of each cognitive domain.Conditioning level differences in overall cognitive function and the level of each cognitive domain in normal people of different groups were compared.Event-related potentials(ERPs)technology was used to collect behavioral(correct rate,reaction time)and electroencephalography(latency and amplitude of N1,P2,N2,and P3)data when subjects completed the More-odd Shifting task.The differences in switching function of normal people of different age groups with different levels of emotional regulation were compared.Results:1.The main effect of the emotional regulation level of the total score of ERSG,the score of liver meridian syndrome factor,the score of anxiety factor and the score of depression factor was statistically significant(P<0.05).The scores of the long-term emotional stagnation group were higher than that of the control group.2.The main effect of emotional regulation level of the total score of Mo CA and scores of visuospatial and executive function,delayed recall,and orientation scores were statistically significant(P<0.05).The scores of the long-term emotional stagnation group were lower than those of the control group.The age-level main effects of the total score of Mo CA and the scores of visuospatial and executive function,naming,language,abstraction and delayed recall were statistically significant(P<0.05).These scores gradually decreased by aging.The interaction effect of emotional regulation level and age of the total score of Mo CA,and scores visuospatial and executive function,naming,delayed recall were statistically significant(P<0.05).The scores of each item in the long-term emotional stagnation group decreased faster by aging than those in the control group.3.The main effects of task type on reaction time and correct rate of More-odd Shifting task were statistically significant(P<0.05),and the reaction time was longer and the correct rate was lower under switching task.The interaction effect of emotional regulation level and task type on correct rate was marginally significant(P=0.066),and the correct rate of the long-term emotional stagnation group was lower than that of the control group under the switching task(P<0.05).The interaction effect between the age group and the task type of the correct rate was statistically significant(P<0.05),the correct rate of the 45-65-year-old age group was the lowest under the switching task(P<0.05),and there was no significant difference among the three age groups under the repetitive task(P>0.05).Although the interaction effect of emotional adjustment level,age group and task type on the correct rate was not statistically significant(P>0.05),further analysis found that in the age group of 18-30,regardless of whether repetitive tasks or switching tasks,there was no statistically significant difference in the correct rate between the long-term emotional stagnation group and the control group(P>0.05);in the age group of 30-45 years,there was no significant difference in the correct rate between the two groups under the repetitive task,but under the switching task,the correct rate of the long-term emotional stagnation group was lower than that of the control group,and the difference was marginally significant(P=0.086);however,in the age group of 45-65 years old,whether it was repetitive tasks or switching tasks,the correct rate of the long-term emotional stagnation group was lower than that of the control group,and the differences were statistically significant(P<0.05).4.Under the two task types,each group induced obvious N1 and P2 in the front of the scalp(Fz),N2 in the front and middle of the scalp(Fz/Cz),and P3 in the front,middle and posterior(Fz/Cz/Pz)of the scalp.The main effects of task type were statistically significant(P<0.05)for N1 latency and amplitude,P2 and N2 amplitude,and P3 latency(P<0.05);compared with repetitive tasks,switching tasks reduced faster and smaller N1,larger P2,smaller N2,and faster P3.5.Under the switching task,the N1 amplitude of the Fz electrode in the long-term emotional stagnation group was larger than that in the control group(P<0.05).6.Under the switching task,the P2 latency in the long-term emotional stagnation group was the largest in the age group of 45-65 years old(P<0.05),while there was no statistically significant difference among the three age groups in the control group(P>0.05).For P2 of Fz,the three age groups of the long-term emotional stagnation group showed that the amplitude of the switching task increased compared with the repetitive task,and the difference between the 18-30-year-old(P<0.05)and 30-45-yearold(P<0.05)age groups statistically significant,but in the control group,this phenomenon occurred in the age groups of 30-45 years old(P=0.069)and 45-65 years old(P=0.067),and the differences were marginally significant.7.In the 45-65-year-old age group at the Fz electrode under the switching task,the N2 amplitude of the long-term emotional stagnation group was larger than that of the control group(P<0.05),and there was no significant difference between the two groups under other conditions(P>0.05).8.Regardless of the repetitive task or the switching task,the P3 latency showed a trend of prolonging by aging.The 45-65-year-old age group had the longest P3 latency(P<0.05);the 18-30-year-old age group P3 amplitude at Pz under switching task was larger than the repetitive task(P<0.05),but there was no significant difference in the P3 amplitude at Fz between the two tasks in the age group of 30-45 and 45-65 years old(P>0.05);the amplitude of P3 at Fz under repeated tasks(P=0.070)and switching tasks(P=0.080)in the age group of 45-65 years in the long-term emotional stagnation group was smaller than that in the control group;while in the 18-30-year-old age group,it was higher than that in the control group under switching task.The amplitude of P3 at the Pz was greater in the long-term emotional stagnation group(P=0.053).Conclusions:1.The high neuroticism population had higher levels of liver meridian symptoms,anxiety and depression.Therefore,the selection of the research subjects was reasonable.2.Long-term emotional stagnation caused liver failing to govern conveyance and dispersion accelerate the process of cognitive function decline in normal population with aging,which may be closely related to the early impairment of visuospatial and executive function,naming and delayed recall cognitive domains.3.The switching function of adults gradually declines with aging.Liver failing to govern conveyance and dispersion caused by long-term emotional stagnation accelerates the process of the decline of switching function.The increasing demand for selective attention resources for early processing of stimuli,and the decreasing capacity of retrieval and update of stimulus-response associations and reduced variability in the reaction selection process are some of the possible mechanisms. |
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