Associations Between Thyroid Diseases And Metabolic Diseases In Adults In Hubei Province

ObjectiveTo investigate the prevalence of thyroid diseases and metabolic diseases in Hubei province.MethodsWe conducted the study in Huazhong University of Science and Technology community of Wuhan City and Yiling area of Yichang City in Hubei Province.Each subject filled out questionnaires,underwent physical examinations,thyroid ultrasonography,and glucose tolerance test.Thyroid hormones,thyroid antibodies,blood glucose,glycosylated hemoglobin,blood lipid,and uric acid were measured.After excluding the subjects who did not meet the inclusion criteria and who had incomplete data,2664 subjects were eventually included in the analysis.ResultsThe prevalences of overt hyperthyroidism,subclinical hyperthyroidism,overt hypothyroidism,subclinical hypothyroidism,goiter,and thyroid nodules among adults in Hubei Province were 0.23%,0.53%,1.2%,17.42%,0.75% and 17.00%,respectively,and the prevalence in females were higher than in males.The prevalences of abdominal obesity,hypertension,diabetes mellitus,hypertriglyceridemia,high LDL-C,hyperuricemia,and metabolic syndrome were 28.68%,37.95%,10.62%,21.77%,24.10%,12.73% and 27.40%,respectively,and the prevalences in males were higher than in females.With the increase of ages,the prevalences of subclinical hypothyroidism and thyroid nodules increased in both males and females,and the prevalences of metabolic diseases showed an obvious upward trend(P < 0.05).After 50 years old,the prevalences of hypertension and hyperuricemia in men were 62.59% and 19.86%,respectively,while the prevalences of hypertension and hyperuricemia in women were 60.91% and 11.51%,respectively.The prevalences of abdominal obesity,high TG,high TC,high LDL-C,low HDL-C and metabolic syndrome in men were 38.11%,24.71%,39.49%,30.95%,14.32% and 38.80%,respectively,while those in women were 40.53%,28.54%,52.04%,31.18%,23.80% and 45.32%,respectively.The prevalences of high TG,high TC,low HDL-C,hyperuricemia,and metabolic syndrome in rural areas were 26.58%,33.20%,19.87%,15.80% and 29.45%,respectively,while those in urban areas were 17.51%,27.29%,14.46%,9.99% and 25.58%,respectively.ConclusionsThe prevalences of thyroid diseases in women were higher than those in men,while the prevalences of metabolic diseases in men were higher than those in women.After 50 years old,the prevalences of hypertension and hyperuricemia were higher in males than in females,while the prevalences of abdominal obesity,dyslipidemia and metabolic syndrome were higher in females than in males.The prevalences of obesity,dyslipidemia,hyperuricemia,and metabolic syndrome in rural areas were higher than those in urban areas.We still need to monitor the prevalences of thyroid diseases and metabolic diseases,and focus on the prevention and control of thyroid diseases and metabolic diseases.ObjectiveAlthough there were many studies focused on the relationship between subclinical hypothyroidism and metabolic diseases,there existed some controversies.And whether thyroid antibodies had some impact on the relationship between them was not clear.MethodsWe conducted the study in Huazhong University of Science and Technology community of Wuhan City and Yiling area of Yichang City in Hubei Province.Each subject filled out questionnaires,underwent physical examinations and glucose tolerance test.Thyroid hormones and thyroid antibodies,blood glucose,glycosylated hemoglobin,blood lipid,and uric acid were measured.Subjects with complete personal basic information,complete thyroid index data,and metabolic index data,without the history of thyroid diseases and serious chronic diseases were included.Subjects with hyperthyroidism,subclinical hyperthyroidism,and hypothyroidism were excluded.Eventually,a total of 2570 subjects were included in the analysis.ResultsSubclinical hypothyroidism was associated with the increased risk of hypertriglyceridemia(OR 1.47;95%CI 1.12-1.93;P=0.005)and Low-HDL(OR 1.39;95%CI 1.05-1.85;P=0.022).In the TPOAb(+)group,subjects with subclinical hypothyroidism had a 3.08-fold increased risk of abdominal obesity(OR = 4.08;95%CI 1.46-11.35;P=0.007),a 2.35-fold increased risk of hypertriglyceridemia(OR =3.35;95%CI 1.43-7.84;P=0.005),and a 1.97-fold increased risk of metabolism syndrome(OR 2.97;95%CI 1.24-7.08;P=0.014)compared with subjects with the normal thyroid function.In the Tg Ab(+)group,subjects with subclinical hypothyroidism had a 2.20-fold increased risk of abdominal obesity compared with subjects with normal thyroid function(OR 3.20;95%CI 1.21-8.48;P=0.019).ConclusionSubclinical hypothyroidism was associated with hypertriglyceridemia and Low-HDL.Tg Ab(+)subclinical hypothyroidism patients had an increased risk of abdominal obesity,while TPOAb(+)subclinical hypothyroidism patients had a higher risk of abdominal obesity,hypertriglyceridemia,and metabolic syndrome.BackgroundThere existed some controversies about the increase of thyrotropin(TSH)levels within the normal reference range and the risk of metabolic diseases.Therefore,the purpose of this study was to explore the association between different TSH levels within the normal range and metabolic diseases.MethodsWe conducted the study in Huazhong University of Science and Technology community of Wuhan City and Yiling area of Yichang City in Hubei Province.Each subject filled out questionnaires,underwent physical examinations and glucose tolerance test.Thyroid hormones,thyroid antibodies,blood glucose,glycosylated hemoglobin,blood lipid,and uric acid were measured.Finally,a total of 2004 subjects with complete personal basic information,complete thyroid index data,and metabolic index data,within the normal thyroid function range,without the history of thyroid diseases and serious chronic diseases were included in the analysis.ResultsAfter adjusting for confounding factors,compared with metabolic data in T1 group,diastolic blood pressure(DBP)and triglyceride(TG)in T3 group were increased 1.47 mm Hg(β=1.47;95%CI 0.17-2.76;P=0.026)and 0.15 mmol/L(β=0.15;95%CI 0.00-0.30;P=0.044),respectively.Subjects in T3 group had increased risk of hypertension(OR 1.41;95%CI 1.04-1.91;P=0.026),diabetes mellitus(OR 1.66;95%CI 1.05-2.62;P=0.029),and hypertriglyceridemia(OR 1.48;95%CI 1.04-2.09;P=0.028).Each SD increase in TSH was associated with higher DBP(β=3.70;95%CI 1.20-6.21;P=0.004)and TG(β=0.29;95%CI 0.01-0.58;P= 0.044).ConclusionThe elevation of TSH levels within the normal reference range was related to the risk of metabolic diseases,which is mainly related to hypertension,diabetes mellitus,and hypertriglyceridemia.Therefore,people within the normal thyroid function range but with high levels of TSH also need to pay attention to the risk of metabolic diseases.