Clinical Study On The Relationship Between Fatty Liver And Histological Types Of Lung Cancer

Part Ⅰ Histological types of lung cancer and their influencing factors Objective:To study the clinical features of patients with different histological types of lung cancer,and find the influencing factors of the changeMethods:A retrospective analysis of clinical characteristics in different histological types of lung cancer,in the department of thoracic surgery of Shanghai Pulmonary Hospital in 2009 and 2013Results:There were 4292 cases of lung cancer patients,62.1%of them were male;average age was 60±9.9 years old;pulmonary adenocarcinoma accounted for 59.5%of all the patients.The proportion of pulmonary adenocarcinoma increased with the increasing of body mass index.Compared with 2009,the percentage of female and adenocarcinoma patients,average age and body mass index were significantly higher in 2013.There were also significant differences in blood biochemical parameters,but no obvious change in smoking rates(42.5%in 2013,vs 42.1%in 2009).The average age in male patients were 2.6 years older than femaleConclusion:Pulmonary adenocarcinoma is one of the most important histological types of lung cancer.Women and obesity are probably two main factors related to the high incidence of pulmonary adenocarcnomaPart Ⅱ Relationship between fatty liver and different histological types of lung cancerObjective:To investigate the proportion of fatty liver in patients with different histological types of lung cancer and its relationship with pulmonary adenocarcinoma Methods:In a retrospective study of clinical characteristics of patients with lung cancer,who had results of liver ultrasound in hospital,explore the proportion of fatty liver in patients with different histological types of lung cancer and their related factorsResults:There were 3664 cases of lung cancer in all,and the proportion of fatty liver was 22.0%,that in 2013(611/2609,23.4%)was significantly higher than 2009(196/1055,18.6%).And the proportion of patients with adenocarcinoma(545/2189,24.9%)was significantly higher than that of squamous cell carcinoma(150/898,16.7%)and small cell lung cancer(16/86,18.6%).Lung cancer patients with fatty liver always had obvious metabolic disorders.Multiple regression analysis showed that the occurrence of adenocarcinoma in lung cancer was independently associated with fatty liver(OR 1.281,95%CI 1.025-1.600),obesity(OR 1.391,95%CI 1.135-1.704),male(OR 0.259,95%CI 0.208-0.323)and smoking(OR 0.588,95%CI 0.486-0.712).Obesity and abnormal transaminases would not increase the risk of adenocarcinoma in lung cancer patients with fatty liverConclusions:The proportion of fatty liver in patients with lung cancer is increasing,especially in patients with adenocarcinoma.Fatty liver may be an independent risk factor for the high incidence of adenocarcinomaPart Ⅲ Relationship between metabolic syndrome and different histological types of lung cancerObjective:To investigate the relationship between metabolic syndrome(MetS),its various components and lung cancer,in particular lung adenocarcinomaMethods:We analyze the relationship between MetS,its components and different histological types of lung cancer in a retrospective study of patients with lung cancer in 2013.Results:There were 675 cases of lung cancer patients who had all the examinations we needed,and the proportion of MetS was 24.4%.The proportion of MetS in adenocarcinoma,squamous cell carcinoma,and other types of lung cancer was 25.7%(117/456),22.3%(33/148),21.1%(15/71),respectively.In each component of MetS,only the proportion of elevated triglycerides was higher in pulmonary adenocarcinoma than squamous cell lung carcinoma(25.4%vs 17.4%).With the accumulation of metabolic syndrome components,the percentage of pulmonary adenocarcinoma raised.Compared with fatty liver in lung cancer patients,MetS did not increase the risk of lung adenocarcinomaConclusion:In lung cancer,particularly adenocarcinoma,patients were usually accomplished by metabolic disorders.Hypertriglyceridemia and fatty liver were closely related to adenocarcinoma,but MetS might not be related to the different histological types of lung cancer.