The Study Of Clinical Characteristics In Dry Eye Patients

Chapter 1.The Study of Clinical CharacteristicinDry Eye Patients Purpose:To investigatethe clinical profile of dry eye patients and help treating this disease.Methods:In this cross-section multicentre observational study,questionnaire survey of 3466 dry eye patients were collected from different regions of China from May 2013 to Oct.2013.All patients completed an interview-assisted questionnaire on dry eye symptoms and underwent measurement of tear break-up time(BUT),slit-lamp evaluation of corneal staining and meibomian gland,and Schirmer's Test ?.Results:The final study patients consisted of 2193 women(65.84%)and 1138 men(34.16%).Mean age of the subjects was 44.7 ± 16.6.The mean score of OSDI was 36.6 ± 16.8.BUT of women was lower than men(4.4 ± 2.7 vs 4.5 ± 2.7,P=0.005).OSDI of Southerner was lower than Northerners(37.3±15.7 VS 37.9±18.3,P=0.003).Dryness was the most frequently reported symptom in ocular surface disease in our study(60.58%).The most frequently repaorted environment triggers was sandstorm(86.3%).Passive smoking was documented in 21.1%dry eye patients.66.3%of patients reported that nevee take participated in sports activities.Only about 30.6%of dry eye patients had a great sleep quailty.Hypertension was one of the commonest systemic diseases in dry eye patients(5.4%),followed by diabetes(5.0%).Significant differences were found among the above 6 groups of differenct gender,living habits,and sysmitic deseases of patients in the scores of OSDI,or ST-?,BUT,FL,meibomian gland(P<0.05).The clinical test of dry eye were not significantly different from those who drink and did not drink,who had a history of allergic disease and did not,and those who use hypnotics,psychiatric medications,antiallergic drug and did not.Conclusion:The risk factors for dry eye disease was multitudinous.The symptom and clinical test of dry eye in patients,those with female sex,region,passing smoking,taking less sports activities,poor sleep quality,hypertension or diabetes,were more seriouse than those without.It may be effective for treating dry eye with assisted treatment included avoiding contact with risk factors,improving the living habits,and treating systemic diseases.Chapter 2.Compared the Clinical Characteristics of Dry Eye among Men and Women PatientsPurpose:To explore the clinical characteristics of dry eye in women,understand the differences between men and women.Methods:The patients with dry eye were collected from ophthalmic clinic,then a cross-sectional study was performed,2193 women with dry eye and 1193 men with dry eye were included.The clinical data of patients with dry eye were retrospectively analyzed,including OSDI,slit lamp examination,tear film break-up time(BUT),Schirmer's Test I,corneal fluorescein staining and meibomian gland function checks.Results:In this study,the average age of women patients was 45.5 ± 16.2 years,and 43.0±17.3 years for men.Controlling for age,among the group(<40 years),the OSDI score of female was higher than men(P=0.044).Women with dry eye were more likely to report problems with eye pain([odds ratio]OR=1.13,95%[confidence interval]CI 1.01 to 1.26,P=0.027);using a computer(OR=1.14,95%CI 1.02 to 1.28,P=0.018);staying in the conditioning room(OR=1.14,95%CI 1.14 to 1.25,P=0.013);having a poor sleep(OR=1.23,95%CI 1.10 to 1.39,P<0.001);wearing corneal contact lens(OR = 2.26,95%CI 1.54 to 3.31,P<0.001);thyroid disease(R ?2.26,95%CI 1.54 to 3.31,P<0.001).In another group(?40 years),the score of BUT,lid margin and meibomian orifices in women with dry eye were lower than men.Women with dry eye were more likely to report problems with photaesthesia(OR =1.09,95%CI 1.00 to 1.17,P=0.033);vision fluctuation(OR = 1.13,95%CI 1.05 to 1.22,P=0.002);sad(OR = 1.62,95%CI 1.21 to 2.17,P=0.001);having a poor sleep(OR-1.27,95%CI 1.16 to 1.39,P<0.001);thyroid disease(OR = 2.25,95%CI 1.09 to 4.64,P= 0.028).Conclusions:Compared with men with dry eye,women with dry eye contact with more risk factors than men.The symptoms clinical test of dry eye in women were different from the men.Chapter 3.Association Study of Sleep Quality and Duration with DryEyePurpose:To study the association of sleep quality and duration with dry eye in dry eye patients.Methods:A total of 3331 dry eye patients were recruited.The clinical data of dry eye patients,those with different sleep quality,sleep duration and fall-sleep time,were retrospectively analyzed,including OSDI,slit lamp examination,tear film break-up time(BUT),Schirmer's Test I and corneal fluorescein staining.The classification of data and ranked data between groups were compared using chi square test.Construction of the general linear model,adjusted for age,gender and other control variables,comparison the clinical data of dry eye patients with different sleep quality,sleep duration and fall-sleep time.Results:The rate of sleep affecting dry eye in the well and poor sleep quality groups were 44.4%and 64.8%respectively.There were significant differences between poor sleep quality and well sleep quality about OSDI(),BUT and ST-?.The rate of sleep affecting dry eye in the sleep time<6 h,6-8 h and>8 h groups were 55.1%,46.8%and 39.9%respectively.There were significant differences between shorter sleep duration(<6 h)or general sleep duration(6-8 h)and longer sleep duration(>8 h)about OSDI and FL.The rate of sleep affecting dry eye in the sleep time<30 min,30-60 min and>60 min groups were 46.8%,65.0%and 73.3%respectively.There were not significant differences among different fall-sleep time about OSDI and the clinical test of dry eye.CONCLUSIONS:A decline in the quality of sleep and sleep duration can aggravate the symptoms of dry eye.The poor sleep quality can shorten BUT,decresed ST-?.