Clinical Study On The Methods Of Reinforcing Kidney And Resolving Dampness And Activating Blood Circulation Treating Chronic Renal Failure

Chronic renal failure (CRF) is an ordinary and difficult disease which resulted from allkinds of primary or secondary kidney disease. Traditional Chinese medicine has treated thedisease for many years. It has multiple methods and makes a good curative effect. Thisstudy discuss the life quality measurement table of CRF and the rule of the diagnosis andtreatment methods, such as tonifying kidney and clearing heat and draining dampness andactivating blood. This paper includes three part .The first part reviews traditional Chinesemedicine and modem medicine in treating CRF. The second part is theory study. First, weindicate that kidney insufficiency damp (heat) blood stasis is the basic mechanisms of CRF.The CRF has the heredity susceptibility. Kidney insufficiency is the TCM characteristic ofthe heredity susceptibility, whose substance base is kidney essence. The theory "kidneycontrolling bone and producing marrow" has relationship with immunity abnormity.Dampness and heat is the main interspaces of CRF. Blood stasis is the main pathologyoutcome, which reversely aggravate the progression of CRF. We bring forward that methodof tonifying kidney and clearing heat and draining damp and activating blood to treat CRF.Second,we discuss the life quality measurement table of CRF. We retrospect the conceptand development of life quality and summarize the kidney life quality measurement table.The third part is clinic study, analysis the ccr and the regress equation of time and 1/scr. Inaddition, we analyzed the TCM syndromes of different phase of CRF. Furthermore wecompare the difference of blood pressure, blood fat, blood sugar and urine proteins beforeand after treatment, we analyze the acute aggravating factor of CRF. Furthermore, combineSF-36 and KIDNEY DISEASE QUALITY OF LIFE SHORT FORM, VERSION1.3(KDQOL), base the clinic symptom of predialysis patient., Take out the question aboutdialysis patient and add part question.Objective: 1 studies the rule of method of tonifying kidney and clearing heat and drainingdamp and activating blood treating CRF.2 set up life quality measurement table to adapt to Chinese patient of CRF.Discuss the relation of the table with TCM symptoms and bun\scr. Provide scientificmethod to make assessment of the therapy.Methods:1 collect the case of CRF from september1995 to December 2006.according toCockcroft-Gault calculate ccr. Ccr(ml/min)=[(140-age)×kg×(0.85female)]/72×scr. Base on the regress equation of time and 1/scr, count b. Assess the decreaserate of kidney function.2 combine SF-36 and KIDNEY DISEASE QUALITY OF LIFE SHORTFORM, VERSION1.3 (KDQOL), base the clinic symptom of predialysis patient.,Take out the question about dialysis patient and add part question. Investigate 30 casepatient of CRF with questionnaire form. Analyze the outcome with kruskal-wallis test.Results:1 The long time analysis indicate that after the treatment of tonifying kidneyand clearing heat and draining damp and activating blood, The b of patientfrom-0.0294±0.2664 before treament increase to 0.0028±0.0196 after treatment, Z=3.317, p=0.001, p＜0.01. the ccr of patient become stable(Ccr29±13.15 beforetreatment; Ccr29.59±16.28 after treatment,p＞0.05)。2 the questionnaire of life quality has a stable of reliability (F=14.6023, P＜0.0001) and variance (α=0.9190) .corelation analysis indicates that the kidneydisease has a relationship with health and daily life and the satisfaction to medicinestaff. The correlation is 0.439 (p＜0.05), 0.654 (p＜0.01), 0.393(p＜0.05) separately;It has a negative relationship with TCM syndrome. The correlation is -0.411. in nineaspect ,the influence of kidney disease to sex life is omiment (23.33±7.854) ;secondly comes the health self-assessment (31.67±3.778) ;the influence onwork is divide to two part, one is the influence of health to work(37.5±2.15),anotheris the emotion to work (49.72±3.45) .the satisfied to medicine and the influence todaily life and clinic symptoms are count high, the score are(68.97±4.375)(67.23±2.38)and (61.5±2.37)separately.(p＜0.05) Conclusion:1 method of tonifying kidney and clearing heat and draining damp and activatingblood can improve the development of CRF.THE possible mechanisms is regulatinglipid reduce the protein urine and improve the risk factors to slow down theprogression of chronic CRF.2 The questionnaire of life quality of chronic renal failure was suitable to CRFpatients. It has a stable of reliability and efficacy. This is the good attempts to usingthis questionnaire in Chinese patients.After using tonifying Kidney and activating blood, the life quality of patientshad agood improvement in some aspects.