The Clinical Observation And Experimental Of Research About The Relieving Of Knee Osteoarthritis By Meridian Scraping Therapy

Objective:1.Explore the meridian scraping therapy for knee osteoarthritis joint activity, joint pain and improve quality of life.2.Due to analyzing the expression of MMP 1 in KOA rabbit articular cartilage, MMP-13 and â…¡ type collagen.we can further verify the clinical curative effect of meridian scraping therapy in the treatment of KOA and explains some of its action mechanism.Method:Due to using Lysholm scale, visual analog scale (VAS),evaluation of quality of life scale to estimating joint activity in patients with knee joint pain, pain index and the quality of life, and so on,in 30 cases of KOA meridian with scraping therapy. In animal experiments section.we use method of Hulth to manufacture the model of knee osteoarthritis.which looked at the rabbit model of KOA meridian scraping therapy rabbit gait evaluation and morphology.By means of immunohistochemical technology,we test of rabbit knee osteoarthritis MM.P-1, MMP-13 and articular cartilage â…¡ type collagen expression.Result:30 cases in meridian scraping therapy group,5 cases recovery(16.67%),5 cases excellent(16.67%),14 cases effective(46.67%),6 cases no change(20%). Significant efficiency: the total effective rate 33.33%:80%.30 cases in physical therapy group:0 cases recovery (0%); Scases excellent 16.67%); 20 cases effective(66.67%),5 cases no change(16.67%). Efficiency:16.67%; The total effective rate 83.33%. Although meridian scraping therapy group total effective rate is slightly lower than physical therapy group, but its efficiency is more than double that of physical therapy group, but no statistical difference was found between the two groups (P>0.05). Tip two groups have certain curative effect on KOA. Meridian scraping therapy and physical therapy groups through a course of intervention, and group internal Lysholm scale between the two way, VAS score and quality of life have different grade, and had statistical significance (P<0.05). That meridian scraping therapy is better than physical therapy in improving the symptoms of patients with joint pain relief aspect, so it is worth popularizing clinically used.Making gait assessment before and after treatment.When the impression is made 4 weeks.in other words, before intervention the meridian scraping therapy.western medicine group, model group animals are serious limping, after the intervention model group animals are still serious.But experimental animal gait scores declined between craping complex therapy group and western medicine group.So that prompt the meridian scraping therapy and oral western medicine can obviously improve the rabbit knee osteoarthritis model of behavioral science.After intervention, using immunohistochemical technique detection of chondrocytes on MMP-1, the expression of MMP-13. â…¡ collagen.The results are as follows:MMP-1: compared with model group, meridian scraping therapy, western medicine group, each expression significantly reduce blank group, the difference was statistically significant (P< 0.05); Compared with the blank group, meridian scraping therapy group and western medicine group expression increased (P<0.05); MMP-13compared with model group, meridian scraping therapy group, each expression significantly reduce blank group, the difference was statistically significant (P<0.05); Type â…¡ collagen:compared with model group, meridian scraping therapy group, western medicine group, the blank group each expression increased (P<0.05); Compared with normal group, meridian scraping therapy group and western medicine group expression decreased (P<0.05). Prompt the meridian scraping therapy and oral western medicine can significantly reduce the MMP-1 in cartilage, expression of MMP-13, increase the expression of type â…¡ collagen, less damage to the cartilage, protect cartilage, delay the degeneration of KOA joints.Conclusion:1. The meridian scraping therapy can obviously relieve knee osseous arthritis sufferers activity, relieve pain symptoms.2. The meridian scraping therapy improve the gait of KOA model rabbit.3. The meridian scraping therapy can decrease the expression of MMP-1 in articular cartilage, MMP-13 and increase the content of type â…¡ collagen.So that to protect from damage of articular cartilage, delay aging joints.