Efficacy And Mechnism Research On Treating Postherpetic Neuralgia By Blood-letting Puncturing And Cupping Therapy

Purpose:Evaluate the clinical efficacy of blood-letting punturing and cupping therapy in treating PHN synthcticly through clinical research and explore the mechanism.Method:1. Introduction randomized control trial,all64patients were divided into treatment group and control group randomly.2.Treatment group(32):Method:blood-letting punturing and cupping therapy.Acupoints:A shi point.Needles:Disposable sterile syringes.Cups:Negative pressure cupping.Manipulations:Sterilize and expand the skin, prick the points multiple-superficially.1.Ocm far from the other needle.Take5-7pricks for each cup area with the depth of3-5mm.Take5-7cupping for12-20minites and gain the blood every other day,8times as a course of treatment. Control group (32):Pregabalin (Lyrica)150mg po, bid, for16days. Observe the effect after1course of treatment.3.Indicators:Comprehansive therapeutic effect,Pain scale-a visual analog scale(VAS), Self-Rating Depression Scale(SDS), Substance P(SP) in peripheral and local blood.Results:1.Comprehensive therapeutic effect:The total effective rate of treatment group is100%,while curative and marked effective rate87.50%; The total effective rate of control group is87.50%,while curative and marked effective rate40.63%.The difference was statistically significant(P<0.01).2.Pain assesment:Pain assessment compared to pre-treatment VAS score was no statistical difference between the two groups(P>0.05);Two of their respective VAS score after treatment compared with before treatment were significantly diffecrent(P<0.01);the two groups after treatment compared to treatment group VAS score was significantl lower than the control group(P <0.01);the time of the pain started to ease of treatment group is significantly shorter than the control group,the difference is statistically significant(P<0.01).3.After treatment,insomnia took a significant better turn in treatment group,exerting efficacy difference between the two groups(P<0.01).4. After treatment,emotion took a significant better turn in treatment group,exerting efficacy difference between the two groups(P<0.01).5.The level of SP in local blood reduced significantly after treatment in treatment group; The level of SP in peripheral blood reduced significantly after treatment in both group, exerting efficacy difference between the two groups(P<0.01).Conclusion:Blood-letting punturing and cupping therapy can obviously relieve the pain of PHN patients,improve the patients’sleep efficiency,improve their imotion states,with better curative and marked effective rate and time of the pain started to ease. It has no side effects,is Safe and worthy of clinical application. Blood-letting punturing and cupping therapy can significantly reduce the level of SP in pain area,which could be one of the mechanisms of pain relief.