The Clinic And Mechanism Study On ShuangShiTangAndErZhiWan Prescription In Treating Early Rena1Damage In Essential Hypertension

Articlel summary of professor yang qunyu’s clinical exper iences and academic thoughtChapter Ⅰ summary of traditional chinese medicine’s research into hypertensionThe shape and develop of hypertension’s etiology and pathogenesis has experienced "the upper shortage leads to dizzy state ","The wind, hot, sputum leads to dizzy state ","Blood stasis leads to dizzy state ", and the theory is perfected gradually. in the recent years. the study of etiology amd pathogenesis of hypentension has been deeply researched constantly. Combining her own clinical experiences with the inspiration of the above ancients’and colleagues’experiences, professor yang qunyu puts forward her own original opinion on pathogenesis of hypentension, which thinks that Xu of the kidney is the fundamental cause of hypertension, liver-yang hyperactivity and blood stasis is its sign, insists that the principle of treating hypertension is to tonify kidney, flat liver, and invigorate the circulation of blood. under the guidance of the theory, professor yang has created her prescription "Shuang Shi Tan " on the basis of her own clinical experiences. the clinical obserservation and research for years shows that the prescription has good effect on lowering blood pressureChapter Ⅱ summary of professor yang qunyu’s clinical experiences and academic thought1. summary of professor yang’s academic thoughtprofessor yang emphasizes Treatment based on Syndrome differentiation combining disease di fferent iation with Syndrome differentiation and Treatment tailored to the individual. she places emphasis on the use of Chinese medicine for activating blood circulation and eliminating stasis when she cures macronosia. she advocates Widening the sentiment, treating due to illness condition, and so on. these academic thoughts can be seen through out all aspects of her clinical treatment2. professor yang’s linical experiencesprofessor yang treats medical disease due to illness condition, her original experiences are worth inheriting and promotingArticle Ⅱ The Clinic and Mechanism Study on ShuangShiTangandErZhiWan Prescription in Treating Early Renal Damage in Essential Hypertensiondamage of heart, brain and kidney caused by hypertention is the main reason that leads to disablement and death. hypertention threatens the health of human being severely. during the early renal damage in Essential Hypertension, if active efforts are made, the function of kidney can be reversed therefore, it is an important research problem to strengthen the research into the early renal damage at present. and it is urgent to develop renal protection medicine which can lower blood pressure lastingly and smoothlyⅠ. reviews of literature1. Chinese traditional medicine’s study on the etiology, pathogenesis and treatment of the renal damage in Essential Hypertension.(1) In Chinese traditional medicine, renal damage in Essential Hypertension has not a corresponding name, physicians in history had little statement on it, and their record is short of deep and systemic understanding. at present, early renal damage in Essential Hypertension in Chinese traditional medicine theory is seldom reported, let alone systematic treantment and prediction(2) Treatment on renal damage in Essential Hypertension is varied in Chinese tradional medicine, the comprehensive use of varied technology and methods is the main tendency and invevitable development trend2. Western medicinel understanding in renal damage in Essential HypertensionThe etiology of renal damage in Essential Hypertension is complex. by testing microalbuminuria and other more sensitive index for the disease, renal damage in Essential Hypertensioncan can be detected and prevented early, The principles of treatment is mainly attached to the prevention and control of hypertension, and require individuation. The ultimate goal is to control the risk, protect target organ, improve patients’ surial rates.3. clinical research into Shuang Shi Tangbased on the clinical experiences, Professor Yang Qunyu created the formula of ShuangShi Tang, which is to increase Ying and Reduce Yang, extinguish the wind, promote the circulation of blood. It is an effective method to cure hypertention. clinical research also shows that the prescription can protect endothelial, improve insulin resistance, reduce hemorheology indices, lipid, and so on. As to the actual situation of patients with hypertension, to TCM syndrome, the prescription’s effect is more significant.4. clinical research of Er Zhi WanEr Zhi Wan originally appeared in "Yi Fang Ji Tie". it is make up by fructus ligustri lucidi and Eclipta alba extract according to the ratio of one to one. Its function is to nourish liver and kidney. it is used to treat different kinds of kidney disease in the clinical treatment by adding or substracting to the prescription.Ⅱ. The Clinic and Mechanism Study on ShuangShiTangandErZhiWan Prescription in Treating Early Renal Damage in Essential HypertensionUnder the guidance of tutor, this study combines the basic theory of TCM and modern medical knowledge with the clinical characteristics of renal damage in Essential Hypertension, concludes that the clinical characteristics of renal damage in Essential Hypertension is that Yin deficiency in liver-kidney, Yang strong and blood stasis in kidney collaterals. with ShuangShiTangandErZhiWan in treatment, which can nourish the patient’s liver and kidney, flat liver, extinguish the wind, and promote the circulation of blood to remove collaterals obstruction in the kidney meanwhile, clinical observation is necessary. Based on this, we will Further research the relationship between the prescription and adiponectin. Preliminary discusses the the prescription’s mechanism of lowering blood pressure and Protecting kidneys. ObjectiveTo observe the clinical effect of ShuangShiTangandErZhiWan to treat early renal damage in Essential Hypertension, and the relationship between the prescription and adiponectin.to Probe the effect of the prescription’ lowering blood pressure and reversing the renal damage in Essential Hypertension, to Preliminary explore the possible mechanism of the prescription’s Therapy effect.Methods60patients of Early Renal Damage in Essential HyPertension were divided into two groups at random, they are the treatment group (30cases)and the control group(30cases). Each group is given conventional treatments, the control group is given the BenazeprilHydrochlorideTablets, then the treatment group is added ShuangShiTangandErZhiWan. and12weeks for one period of treatment. the change of blood pressure, the clinical symptoms, the urinary microalbumen excretion, blood lipid, blood rheology and blood adiponectin were observed before and after treatmentResultsthere are no significant differences in the two groups’s gender, age, body weight and body mass index, dietary habits, course of disease, concurrent disease, blood pressure levels, blood pressure classi f’ication, blood pressure risk stratification and single symptoms before treatment (P>0.05).the information analysis shows that the two group are basically on the same baseline before treatment, their results are comparable.The total effective rate of the treatment group is93.3%; and the control group is86.7%. the treatment group can lower blood pressure obviously more than the treatment group (p<0.01). as for the blood pressure change, both group can lower blood pressure (P<0.05), and there is no difference between two groups in6weeks, but the treatment group is better than the control group in12weeks (P<0.05~0.01). The study also shows that the prescription can lowerurinary microalbumen excretion significantly (p<0.05^0.01), improve lipid metabolism(p<0.01), Hemorheology (p<0.05-0.01), and improve adiponectin (p<0.05). its efficacy is obvious better than the control group, meanwhile can markedly improve systemic symptom (p<0.01). And the medicine is safe, fewer side effects.Conclusions ShuangShiTang and ErZhiWan has smooth, moderate effect on lowering blood pressure, and can reverse early renal damage in Essential Hypertension, improve the clinical symptoms. Its effect come true through multiple links and multiple targets, the medicine is an effective prescription to treat early renal damage in Essential Hypertension. Besides, ShuangShiTang and ErZhiWan’s function of lowering blood and protecting kidney may be connected with Serum adiponectinThis study, which inherited and carried forward my tutor’s experiences has deepened theoretically the knowledge in TCM pathogenesis of early renal damage in Essential Hypertension, it provides a new kind of research idea and Treatment agent for reversion of early renal damage in Essential Hypertension, and made a beneficial attempt to enrich Chinese medicine treatment. and for the first time, to study the relationship between the prescription and adiponectin. to Preliminary explore the possible mechanism of the prescription’s effect on lowering blood pressure and reversing early renal damage in Essential Hypertensionm. so, it has some degree of theoretical significance.