Clinical Study Of Differentiation And Treatment Of Traditional Chinese Medication On Optic Atrophy

ObjectiveClinical effectiveness of TCM differentiation treatment on various optic atrophy.Method21 cases consists of 34 eyes with various etiological classification of optic atrophy are divided according to their TCM symptomatic conditions into four categories based on deficiency of liver-kidney, deficiency of qi and blood, qi and liver stagnation as well as yin-deficiency and fire-excess types. The four categories were treated respectively with modified zuoguiyin (to nourish liver and kidney), modified bazhentang (to tonify qi and blood ), modified danzhixiaoyaosan (to regulate liver qi ) and modified zhibaidihuangtang (to nourish yin to clear pathogenic heat). Comparisons were done on data obtained before and after treatment. Statistical analysis were performed on data from visual acuity test, field analysis test, Visual Evoked Potential (VEP) and Heidelberg Retina Tomography (HRT).Results1. There is significant improvement in vision acuity between before and after treatment, p<0.01.2. Light sensitivity and visual defects remained almost constant.3. In the Visual Evoked Potential (VEP) analysis, it is found that P100 peak latency period has significantly reduced, p<0.02 after treatment, while amplitude remained unchanged.4. In Heidelberg Retina Tomography analysis, cup area, cup/disc ratio and rim area are of no significance improvement, p>0.05; however, retina nerve fiber layer thickness has shown a significant increase.5. Based on TCM treatment analysis, it is found that the overall effectiveness is 73.53%.6. There is an observed improvement in effectiveness of treatment for patients with shorter period of disease, however, it is statistically insignificant.ConclusionWith TCM differentiation treatment on various types of optic atrophy, there is an observbed significant improvement in acuity (p<0.01) and a reduction in VEP latency period (p<0.02). Although sample collected was limited to reach a statistical conclusion on parameters done on HRT tests, it is observed that retina nerve fiber thickness increased by 5% as compared to before treatment. It is evident that TCM differentiation treatment has an impact on visual function protection and thus can improve its functionality.