Clinical And Experimental Study Of Sang Xian Granule On Improving Pulse Pressure And Artery Elastic Function In Elderly Hypertension Patients

Objective: Appraise an impact of the Sang Xian granule(SXG) which taking nourishing kidney and promoting blood circulation as effect over the elderly hypertension' s pulse pressure and artery elastic function and discuss the effect mechanism. Methods: 86 cases of elderly hypertension belong to the sydrome of deficiency of kidney and stagnation of blood were observed in clinical trial.All cases were randomly divided into test group and control group, The control group oral Indapamide.and on the basis of this treatment,the test group were treated by SXG, the treatment lasted for 12 weeks.In experimental studies, 10-week-old SHR were given SXG or indapamide respectively by gavage treatment to observe antihypertensive effects and possible mechanism of SXG. Results: The clinical research showed that SXG can lower blood pressure and pulse pressure levels, regulate blood lipids, improve clinical symptoms and arterial elasticity function. Statistics showed that SXG is effective than the control group mostly. In experimental studies, SXG can control blood pressure obviously, regulate vasoactive substances such as ET,NO,TXB₂ and 6-keto-PGF_1α, inhibit the expression of TGF-β₁ and NF-kB in aorta, improve ultrastructure of vascular smooth muscle cells(VSMC) and protect endothelial cells. Conclusion: SXG can lower blood pressure, reduce pulse pressure levels and improve artery elastic function effectively. The effect is better than antihypertensive treatment simply, the mechanism is related to the function of protecting endothelial function.