Knockdown Of NF-κB Signaling Pathway By SiRNA Inhibits The Proliferation And Invasiveness In Cholangiocarcinoma

Surgical resection offers the only chance to cure not only for its difficult of diagnosis but also itself clinical pathological characteristics with infiltration and spread out along the vessel and the nerve sheath. However, the outcome of patients with advanced cholangiocarcinoma still remains the higher rate of tumor recurrence and extremely poor even after resection. Radiotherapy and chemotherapy does not improve survival rate. For the sake of these, it is practical importance to study the precise and effective treatment of cholangiocarcinoma. Epidemiological investigation of risk factors for cholangiocarcinoma is common pathological features of chronic inflammation. NF-κB as a ubiquitous transcription factor, activation abnormal in a variety of tumor cell proliferation and invasive regulation play important of role, is "inflammation-associated carcinoma chain "of key control aspect. The topic is precisely based on this issue cholangiocarcinoma of the main pathological features of chronic inflammation, focus on NF-κB signaling pathway,'inflammation-associat -ed carcinoma chain'the key aspect of regulation, observating the cholangiocarcinoma NF-κB signal expression through the experiments in vivo and in vitro ,and use of NF-κBp65 targeting small interfering technology to block NF-κB signaling pathway to explore the role of anti-proliferation and invasiveness in vivo and in vitro.This paper included 5 sections.