Dispels Poisonous Capsule In The Treatment Of Systemic Lupus Erythematosus (Remission) Theoretical And Experimental Study On The Mechanism

Objective: In the earlier period clinical curative effect's foundation,completes the related literature search, the fundamental research, to thetraditional Chinese medicine compound prescription which independentlydevelops dispels the poisonous capsule, carries on the Pharmacology, theimmunity pharmacodynamics research with the animal experimentationmethod, discusses this side the action mechanism.Method: The system reorganization China and the West medicine tothe systemic lupus erythematosus research's related literature, to its reason,machine, the card, governs proposes individual opinion. And divides intostochastically 75 mice A, B, C, D, the E,5 group, refers to the WHOimmunity research teaching center report the method, selects near junctionis the BALB/C female mouse makes the mold, utilizes the methodobservation which the double immune body contains filling to dispel thepoisonous capsule to lupus mouse circumference blood IL-6, IL-10, IFN-r,the ds-DNA immune body level influence. Takes out its hepatorenalorganization to make the pathological section, observes its pathologychange, and carries on the curative effect determination through the aboveeach group's immune body level and the kidney histology's change situation.Finally: Dispels the poisonous capsule through to suppress lupus typemouse blood serum IL-6, IL-10, IFN-r, with the anti-ds-DNA expression,mediates TH1/TH2 intercellular space balanced, the correction displacementcell factor spectrum, the correction circumference blood T cell and thesubgroup unbalanced condition, the improvement organism immunityenvironment, the correction lupus mouse unusual immunologic functioncondition. From this deduction immunosuppression, the immunityadjustment function possibly is the traditional Chinese medicine dispels thepoisonous capsule to treat SLE the important mechanism.Conclusion: Dispels the poisonous capsule obviously to reduce lupus type mouse blood serum IL-6, IL-10, IFN-r, the anti-ds-DNA immune bodylevel, the curative effect and the strong pine and China and the West unionmedication group compares the non-significance difference, can obviouslyimprove the lupus type mouse liver and kidney's pathological state, enablesthe lupus mouse's hepatorenal function to obtain the certain extentrestoration. Dispels the poisonous capsule through to suppress lupus typemouse blood serum IL-6, IL-10, IFN-r, with the anti-ds-DNA expression,mediates TH1/TH2 intercellular space balanced, the correction displacementcell factor spectrum, the correction circumference blood T cell and thesubgroup unbalanced condition, the improvement organism immunityenvironment, the correction lupus mouse unusual immunologic functioncondition. And in the treatment, has displayed the anti-SARS, strengthensthe non-special immunologic function and has suppressed the high humoralimmunity and the adjustment immunologic function effect, provided the newrelatively poisonous side effect to be small, has certain immunityintervention function traditional Chinese medicine, was the SLE treatmentopens a new way.