Research On Professor Wang Zongren's Academic Experience In Treating Coronary Heart Disease

Professor Wang Zongren is a man of strong moral fiber and good medical technology.He has increased knowledge and experience in treating cardiocerebral vascular disease with integrated traditional and western medicine.He gets used to self-cultivation and leading a quiet life.He usually workes hard on ancient motto and is familiarity with the ancient and present.He believes that it is important to insist on giving attention on both theory and practice,especially on appling what they have learned.He insisted that a diagnosis and treatment is thorough based on a diagnosis in accordance with integrated syndromes and diseases,including both observation of colours and pulse condition and modern tests.He has connected chinese traditional medicine and western medicine,treating on urgent,delay and staging.He put forward to settle the clinical problems with making the past serve the present,and he proposed viewpoint of disease groups " qi deficiency and blood stasis".He believes that it is very important to insist on relating Qi with blood and protecting Yang-Qi in treatment.It is also emphasized protection before the onset of disease by tutor.He developed humanity medical technology for benefiting society and his pupils work all over our country.The tutor's academic experience is summarized from the above ten aspects in this paper.Angina pectoris in coronary heart disease is a frequently-occurring disease that is commonly seen in cardiovascular system.Angina pectoris has been seriously threatened the people's life and quality of life with ascending incidence in recent years.The injury of vascular endothelial cell,activation of platelet and blood coagulation factors,imbalance of procoagulation and anticoagulation, hyperlipoidemia and especially inflammation factor could conrtibute to cause plaque instability and secondary thrombosis.Based on the theory of traditional Chinese medicine(TCM),predecessors' experience and understanding of clinical practice,Prof.Wang Zongren thinks that angina pectoris belongs to the "chest bi-syndrome" or "cardialgia" category in TCM,and Qi deficiency and blood stasis is the TCM's key of pathogenesis of "cardialgia".So boosting Qi and activating blood therapy is basic therapeutic principle of "chest pain".A formula designated Qidan Tongmai Tablet(QDTMT) was developed by tutor.And QDTMT consists of compounds of extractives of traditional Chinese herbs from dried roots of Astragalus membranaceus,Saliva miltiorrhiza(Labiate),Angelica sinensisi (Umbelliferae),the dried flower of Carthamus tinctorius(Compositae) and dried twig of Cinnamomum cassia(Lauraceae) and functions as invigorating Qi and promoting blood circulation.The result of research indicated that QDTMT had curative effects in the angina pectoris and palpitation,shortness of breath and languidness.It also prolonged Clotting time and decreased blood fat.As far as the inflammatory media and immune molecular were concerned,the serum levels of IgG and C3,the ratio of CD4~+/CD8~+ significantly lowered in the QDTMT group. The serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitive C-reactive protein(hs-CRP),endothelin-1(ET-1) and homocysteine(Hcy) also notablely decreased in the QDTMT group after treatment.And no obvious and serious side effects were found.In conclusion,QDTMT has specific effect in treating UA patients with the syndrome of blood stasis due to Qi deficiency, indicating that QDTMT could operates through improving anticoagulation and regulating blood fat and immune function,and inhibiting inflammatory reaction. Therefore,it is worthy to be studied deeply.On the other hand,Meta-analysis was carried out to evaluated the the curative effect and safety on angina pectoris due to Qi-deficiency and blood stasis by Qi-supplementing and Blood-Quickening,the results showed that the Qi-supplementing and Blood-Quickening could improve curative effect and decrease adverse reactions.