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The Actuality Of Epidemic And The Analysis Of Riskiness About Non-alcoholic Fatty Liver In DeHui City

Posted on:2009-04-11Degree:DoctorType:Dissertation
Country:ChinaCandidate:S M HeFull Text:PDF
GTID:1114360245463382Subject:Internal Medicine
Abstract/Summary:PDF Full Text Request
In recent years, with the improvement of living standards and changes in lifestyle, non-alcoholic fatty liver prevalence rate increased year by year. Non- alcoholic fatty liver (NAFLD) has become the first major developed chronic liver disease and liver dysfunction leading cause of liver disease in the developed countries. In the incidence of after viral hepatitis of our country, a serious threat to human health. The majority of chronic disease was benign process, fatty liver and fatty liver hepatitis were most common clinically, but a few may develop into liver fibrosis and cirrhosis or even the end-stage liver failure, liver cancer, threating to human health seriously. NAFLD to insulin resistance and the metabolic syndrome as the center close. China started research on NAFLD in the 1990s. Entering into the 21st century research reports increasing results of the study also showed that the prevalence of NAFLD rising, but most of these studies did not distinguish between the etiology, and all the studies are small crowd of specific investigation, we will be used in both urban and rural areas residents of the general population of a large sample multi-stage stratified random sample survey methods currently not yet reported. The Objective of the topics is to explore DeHui City's adult non-alcoholic fatty liver epidemiological status, and risk factor analysis.Objective: Clear prevalence rate of DeHui City NAFLD adult, influencing factors and causes, and hope that through this study clearly the actuality of the adults NAFLD Pandemic in DeHui, to develop effective preventive measures to raise quality of life, reduce medical costs and the burden on the family and society, and provide a theoretical basis for national health policies formulation .Methods: A multi-stage (tiered system) sampling methods of investigation, 6,043 cases of Dehui City adults over the age of 18 conducted a questionnaire survey. Include: age, sex, occupation, education level, income, past medical history, genetic history, alcoholic drinks and tobacco habits, exercise, sleep, eating habits, drinking, medication, and so on. before a formal investigation, all participating personnel need the systematical training, and based on pre-survey, respondents considered gender, age, economic status, compliance and other factors, of 6043 investigator, 3815 cases conducted medical examination, fasting blood glucose and lipids, liver function, hepatitis B, hepatitis C virus markers, blood and other laboratory tests, and real-time sonography. Finally, the 3815 case of those with SPSS13.0 data integrity of the data for statistical analysis. Use of measurement data are few, the standard indicators of poor, count data adoption rate, a ratio of indicators. Categories on the overall distribution of different variables test using X~2 test, P<0.05 a statistical significance. The normal distribution of the continuity of the overall distribution of different variables tested by t test, P<0.05 a statistical significance. Using a Logistic regression to analysis disease risk factors.Results: In the 3815 case of the survey, NAFLD prevalence rate of 15.9%, 18-40 years of age, male than female, over the age of 41, women than men, 41-60-year-old age group high. Peasants, workers, the prevalence rate higher than that of other professions, science, education, the lowest prevalence rate of staff. Married than unmarried. Hypertension, impaired fasting glucose, central obesity, hypertriglyceridemia, low high-density lipoprotein hyperlipidemia prevalence rates were 28.7%, 28.4%, 36.0%, 29.0%, 24.1%. Metabolic syndrome prevalence rate is 22.4%, 18-50-year-old male prevalence rate is higher than women, after 50-year-old female prevalence rate significantly higher than that of men., the above diseases prevalence rate of NAFLD significantly higher than non-fatty liver, respectively, were 49.4%, 33.4%, 81.1%, 56.5%, 29.7% and 39.6%. Logistic regression analysis showed that NAFLD and sex, BMI, fasting blood glucose increased, hypertension, central obesity, metabolic syndrome significantly correlated.Conclusion: The results of this study show that urban and rural residents NAFLD prevalence rate is 15.9 per cent in Dehui City. Prevalence of NAFLD and the sex, occupation, marital status, age related, and sleep, smoking, exercise, diet, income unrelated. The NAFLD prevalence of women is higher than men, married is higher than unmarried, in aged 18 -60 years old, with the age of the growth, prevalence of NAFLD is gradually increasing, 41-60-year-old age group is the high incidence of fatty liver age, after the age of 60 the prevalence rate declined slightly, in the 18-40 years old, male prevalence rate is higher than women, in the 41-50 years of age, women slightly more than men, after 50 years of age, females is higher than that of men. The prevalence of NAFLD and occupations are relevance, the prevalence rate is degressively farmers, workers, office cadres individual operators, enterprises managers. The lowest prevalence rate is science and technology personnel. The prevalence of NAFLD is correlated with obesity, impaired fasting glucose, diabetes, lipid disorders, hypertension and other metabolic disorders. With the superposition associated with of Metabolic syndrome indicators increasing , the prevalence rate of non-alcoholic fatty liver has continuously increased. The prevalence of metabolic syndrome in women is higher than men, and gradually increased with age, 51-60 age group is the high incidence of age, after the age of 60 the prevalence rate declined slightly, 18-50-year-old male is higher than female, after 50 age women was higher than that of men. NAFLD is the first category liver disease in Dehui City, and its prevalence rate was higher than that of viral hepatitis. Fatty liver is the main reason for liver dysfunction.NAFLD and metabolic syndrome are closely related, can be used as components of metabolic syndrome.Improvement of life style, the enhancement of health propaganda and education can reduce the incidence of the NAFLD and metabolic syndrome, and can enhance the entire people's quality of life, and reduce medical costs.The results of this study show that in the investigation of the crowd and the developed areas of our country ,NAFLD the prevalence rate is similar, prevalence rate of metabolic syndrome is higher than the national reports, to illustrate that both of them in China are rapid growth, these are worthy to cause attention and need to take effective control measures to reduce the disease to hazard the human health. Of course, because of the restrictions of experience and conditions , there are still some shortage in this study, which need to further improve in the future.
Keywords/Search Tags:fatty liver, non-alcoholic, epidemiology, prevalence of risk factors
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