Experimental Research. The Hqt Effective Fraction Anti-ulcerative Colitis In Rats

Ulcerative colitis (UC) is one of the most serious gastrointestinal disease. Incidence of UC gradually increases with years. The etiological factor and pathogenesis remain unknown. The major factors generally include heredity, immune, infection and psychosomatic theory. The major symptoms of UC include diarrhea, rectal bleeding, the passage of mucus, tenesmus and abdominal pain, those symptoms is characteristic of inflammatory bowel disease. The onset of UC is acute and patient's condition is great disparity. In general, UC's progress is slow, but it tends to relapse. Severity condition of this disease may be found in some case who are acute. UC has been listed as refractory disease by WHO because it's treatment is very difficulty and frequently relapse, meanwhile, it correlates with cancer of colon. There are some deficiencies of UC's treatment through western medicine, such as frequently relapse after drug withdrawal, there are some side effect after taking medicine in a long time, there is no good effect in refractory case. So, it is the most important research to find effective drug. There are significant superiority, prominent investigation value and wide prospect in the aspect treatment of UC by Chinese medicine.This paper base on systemically arranging literature and tutor's clinic experience, meanwhile, depend on the ways of thinking in the active elements of Chinese medicine research. Pharmacodynamics, taking prescription apart and curative mechanism that compound elements of HuangQinTang and HuangQin Tang treat experimental ulcerative colitis on rat were observed.Pharmacodynamics result show that compound elements of HuangQinTang and HuangQin Tang have good effect of anti-inflammatory, antidiarrhea and relieve pain, meanwhile, it can improve the general condition and histopathologic condition.Taking prescription apart result show that compound elements of HuangQinTang and HuangQin Tang have good effect of anti-inflammatory, antidiarrhea and relieve pain on some extent. The group of Baicalin + Glycyrrhizic acid + Panglycoside of white peony root + cAMP of jujube have the best effect in all group. So, the main substance that HuangQin Tang treat UC are Baicalin, Glycyrrhizic acid, Panglycoside of white peony root and cAMP of jujube.The curative mechanism that compound elements of HuangQinTang treat UC show that IL-1 , IL-4, SOD, MDA had significant difference between model group and normal group ( P < 0.01 ) .Meanwhile,the medium dosage group of compound elementsAbstractof HuangQinTang can significantly decrease the content of IL-1 , MDA and increase the content of IL-4, SOD,which significantly differs from those of the model group ( P...