Cough After A Cold Treatment Efficacy Relevant Factors Research

Cough is a common symptom caused by many diseases in internal medicine. The quality of life and social activities in many patients coule be disturbed by frequent and severely cough.When the cold symptoms disappeared after the acute phase itself, cough still in, and it be called postinfectious cough. Many respiratory infections may cause cough in addition to the respiratory virus. At present, postinfectious cough curative effect factors is rare, and we're wondering the curative effect factors of postinfectious cough and explore the curative effect in different treatment measures.ObjectiveThrough observation of the treatment effect factors in postinfectious cough, the cohort-study method was used, the multiple linear regression analysis was applied to summarize the treatment effect factors and preliminary probe the effect of different treatment measures, so as to provide some references in improving the curative effect of postinfectious cough.Theoretical study:Summarizes the associated curative effect factors of postinfectious cough, and to provide basis for clinical research through the literature research and the expert consensus.Clinical study:Summarizes the main influence factors of postinfectious cough, and compare the effect in different treatment measures.Methods1. The methods of theoretical study:1.1 Literature research:Relevant literature on postinfectious cough in Chinese and Western medicine were reviewed, so as to summarize the treatment effect factors.1.2 Expert consensus:Hall for workshop of metasynthetic engineering and Analytic Hierarchy Process methods were used to add the deficiency of the literature research. The results and literature research results were theorical and practical experience supports for CRF design.2. The methods of clinical study:The multiple-centers, open design, prospective observational, cross-sectional study methods were used. And site questionnaire was applied to collect information of the first clinic patients. Site questionnaire and follow-up phone calls combined to collect information about posttreatment of postinfectious cough.Comparison in the group and comparison among groups before and after treatment, and multiple regression analysis were used for statistical analysis of the collected data to study and summarize the effectiveness in postinfectious cough. Meanwhile we compared the differences of therapeutic efficacy of the three methods in the treatment of postinfectious cough.Results1. The results of theoretical study:1.1 The results of literature research:We obtained 363 articles published in Chinese articles, contained 39.813 patients. The associated factors included gender, age, course, the severity of PIC, routine blood test, X ray, past medical history and sputum cultures results.etc.1.2 The results of expert consensus:We should collect patients information as much as possible.2. The results of clinical study:2.1 A total of 397 cases of patients were observed in the study of effectiveness of postinfectious cough, including 115 males and 282 females; mean age of 46.99±15.74 years; and mean course of 25.62±13.44 days.2.2 Age, course, therapeutic measures and gender were factors related to the therapeutic effect of postinfectious cough.2.3 Cough symptoms and quality of life were improved compared with treatment before in 3 groups, with significant difference (P<0.05). Stratified analysis by gender:After treatment, the female cough symptoms(Cough symptom scores, VAS and total score of LCQ) improved in Chinese traditional medicine group, better than Chinese medicine group and Western medicine group, with significant difference (P<0.05). The male cough symptoms(Cough symptom scores, VAS) improved in Chinese traditional medicine group, better than Chinese medicine group and Western medicine group, with significant difference (P<0.05). The male cough symptoms were not obvious difference in total score of LCQ.2.4 Age, course and gender were factors related to the Chinese traditional medicine of therapeutic effect in postinfectious cough.Conclusions1. Clinically, postinfectious cough is a common syndrome, with a higher incidence in females. Postinfectious cough can be found in all age groups, with the highest incidence in middle-aged group. Most of postinfectious cough duration was less than 8 weeks, it can affect the quality of life of patients in different degrees, especially in female.2. Age, course, therapeutic measures and gender were factors related to the therapeutic effect of postinfectious cough.3. Chinese traditional medicine, Chinese patent medicine and Western medicine had significant effect for treating postinfectious cough, Chinese traditional medicine was the best treatment.4. Age, course and gender were factors related to the Chinese traditional medicine of therapeutic effect in postinfectious cough.