Study On Synthesis And Treamten Of Inectious Wounds Of Taurine Modified Products

We describe the treatment of infective wounds in this disquisition, and analyze the advantages and disadvantages treatment of Chinese Materia Medica(CMM). We suggest the concept of "quantitative effective ingredients group of CMM"and try to solve the key technological problem pertaining to the chemistry of CMM.Based on principle of click chemistry and combinatorial chemistry,25 taurine schiff base compounds were synthesized and identified which including 5 salicylaldehyde aldehydes and 15 benzaldehydes compounds. These compounds were characterized by chemical and spectral methods. All these compounds were first reported. One of the compounds, which was named as 5 Bromosalicylaldehyde taurine Schiff base Potassium, was characterized by X-ray crystal diffraction.The scanning of all compounds on antibacterial activities was investigated, and 5 chlorosalicylaldehyde taurine Schiff base Potassium had a good antibacterial activity, then the minimum inhibitory concentrations(MIC) and minimum bacteriocidal concentration (MBC)experiments were carried out by macrondilution antibacterial tests.The results showed obvious inhibition for Staphylococcus aureus and Klebsiella pneumonia. the breach of wall and membrane along with the outflow of protoplasm in Klebsiella pneumonia treated with 5 - chlorosalicylaldehyde taurine Schiff base Potassium for 18h.The effect of 5 - chlorosalicylaldehyde taurine Schiff base Potassium on infected wound healing process in rat was studied including bacterial amount rate of wound heling,VEGFA mRNA expression and b-FGF mRNA expression by reverse transcriptase polymerase chain reaction (Rt-PCR),VEGFA expression by immunohistochemistry.