| Objective:To form an evaluation system of multi-direction curative effects of TCM on liver cirrhosis and make the most advantages of TCM in treating liver cirrhosis by terms of a process of "study on documents records collect of experts'comments-clinic research".Methods:1.study on document records Meta Analyze the collected document records on curative effects of TCM on liver cirrhosis and conclude an evaluation system characterized with TCM.2.collect experts'comments Set a questionnaire which contains the questions related to the quotes of syndromes, diseases related chemical and etiological index and functional index based on the study of document records and analyze the results of the questionnaire with Delphi method. And then form an evaluation system of multi-direction curative effects of TCM on liver cirrhosis after 2 rounds of investigation.3.clinical research To observe the curative effects, the incidence rate of complications, the quantity of life, social function and psychological situation in terms of clinical research methods of multi-central, random and contrast.Results:1.study on document records Among 436 records we retrieved,6 were qualified to be embodied after reading of the title, abstracts and whole text and screened by Jadad Scale. We Meta analyzed the 6 embodied texts and the results show that TCM shows a better whole effect in treating cirrhosis in an early stage due to hepatitis, especially in the indexes of HA, LN, PCIII, ALT, TBIL AND AST.2.The index with minimal mean is "hepatauxe" and the maximum "blooding nose" in the first round of investigation. And in the second round, the index with minimal mean is "hyposexuality" and the maximum "clinical syndromes described in TCM". We finally established 4 primary indexes,18 secondary indexes and 30 third-class indexes through 2 rounds of combination and deletion. Among those established indexes, the weight coefficient of the 4 primary indexes:TCM syndrome, curative effects of regular western medicine, the quality of life and the incidence rate of complications are separately 0.2649,0.2602,0.2354 and 0.2395.3.TCM shows a significant priority over regular western medicine in ameliorating ALT,TT,APPT,PT,â…£_C and DBIL. The patient with cirrhosis got marks lower than 60 on average, which indicates that they will suffer a bad quality of life later. Two groups of patients got higher marks in all areas after being treated. Compared with before, there's a significant difference (P<0.05) especially in physiology and psychology(P<0.01). Compared with the control group, the treated group also shows a significant difference (P<0.05) when tested in psychological area and overall grade. We found out with social function defection scale, scale of anxiety self-evaluation and scale of depression self-evaluation that most of the patients in the two groups have defection of all degrees either in social or psychological function. The patients in the treated group got lower marks than the control group in social function defection scale (social recession, social activities, domestic function, the interest of the outside world and responsibility) which indicates that TCM has better effects than regular western medicine in social and psychological function.Concludes:The form of evaluation system of multi-direction curative effects of TCM on liver cirrhosis based on the indexes of TCM syndromes, the incidence rate of complications, the quality of life, social function and psychological tests either emphasizes on the characters of TCM of multi-channel, multi-target and wholic regulation or evaluate the clinical curative effects of TCM objectively and provide methods and clues for the evaluation of clinical application of TCM.
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