Studies On The Clinical And Endocrinal Characteristics And Insulin Receptor Substrate 1/2 MRNA Expression Of Polycystic Ovary Syndrome With Phlegm-dampness

Objective:1.To explore the characteristic index of PCOS patients with phlegm-dampness in order to give further basis on standardized diagnosis and treatment of PCOS.2. To explore the moleculau mechanism of IR in PCOS patients with phlegm-dampness.Methods:In clinical study 1,45 normal reproductive-aged women as controls, and 135 PCOS patients were divided into two groups:phlegm-dampness group and non phlegm-dampness group. Serum sex hormone,as well as DHEA-S,FPG,FINS,SHBG levels were measured by chemiluminescence. Indeics above and other parameters (menstrual cycle,BMI, waist size,Homa-IR, FAI etc were compared among groups. In clinical study 1,luteinizing granulosa cells from 20 PCOS patients and 10 patients with normal menstruation as controls were collected, IRS-1 and IRS-2 mRNA expression were examined by semi-quantitative RT-PCR.Results:1.clinical characteristics:menstrual cycle:PCOS groups>control; BMI, waist size:phlegm-dampness PCOS group>control,phlegm-dampness PCOS group>non phlegm-dampness group (P＜0.05).2.sex hormone and DHEA-S:LH,T levels:PCOS groups>control, DHEA-S level:phlegm-dampness PCOS group>control (P<0.01), phlegm-dampness PCOS group>non phlegm-dampness group (P<0.05).3.IR related parameters:FINS,HOMA-IR,FAI:phlegm-dampness PCOS group>control (P<0.01), phlegm-dampness PCOS group>non phlegm-dampness group (P<0.05);SHBG level:phlegm-dampness PCOS group