The Prevalence Of Human Papillomavirus Infection And CIN In Shenyang City

Objectives1,To investigate the HPV infection status and the type-specific distribution of HPVinfection in the urban environment of Shenyang, China, to provide the data forvaccines.2,To analysis the risk factors of high-risk HPV infection, to provide theoreticalevidence to screening and prevention of cervical cancer.3,To investigate the prevalence of CIN and cervical cancer in Shenyang, and toestimate the validity of the screening methods of cervical cancer.4,To investigate the effect of Baofukang suppository made from Chinese herbs onthe HPV infection.Methods1. A list of 1000 women aged 15-59 years were obtain randomly for the study fromthe population, and the questionairy of epidemiology was filled and then inputinto computer. 685 participating women had a sample of exfoliated cervical cellscollected for liquid-based cytology and HPV testing.PCR, ELISA were used todectect the HPV types. VIA,VILI,liquid-based cytology and coloscopy were usedfor screening, and Youden's index was used to estimate the validity of the methodsof screening for cervical cancer.2. 47 cases came from the clinic of Liaoning Tumor Hospital, who were HPVpositive and were excluded CIN, were seperated into three groups randomly, andwere intervened by Baofukang ,Shuangzuotai suppository and nothing.Resueits1. The prevalence of any HPV type was 16.8% among the 685 women, and was89.7% in women with CIN. In all, 32 individual HPV types were identified. Infectionrate of the high-risk HPV was 11.7 %. The most common HPV types in either single-or multiple-type infection in Shenyang were 16 (3.4%), 52 (2.5%) and 58 (1.9%)。High-risk HPV type were found 79.3% of women with cervical abnormalities.2. The average age of subjects was 35.18±13.2 years old. HPV prevalence was notstatistically different across age groups, high-risk HPV types predominated across all age groups, but HPV 16 and 18 tended to diminish among older women.3. HPV prevalence was similar among women who were divorced/separated orwidowed, who showed significantly higher prevalence than married women. Multiplelifetime sexual partners and husband extramarital sexual relationships weresignificantly associated with HPV positivity. No significant association was foundbetween HPV positivity and age at first sexual intercourse, contraceptive methods,education level, occupation and births.4. Among 685 cases, 23 cases (3.4%) had histologically confirmed cervicalabnormalities, including 12 CINⅠ, eight CINⅡand three CINⅢ(1.6%,include CINⅡand CINⅢ).Cervical cancer was not found.5. The study shows that among the screening methods we used, coloscopy orliquid-based cytology combined with coloscopy are better.6. The drugs intervening has no significant effect on the HPV quantity.Conclusions1. HPV prevalence was not statistically different across age groups, high-risk HPVtype predominated in women with cervical abnormalities. HPV types in either singleor multiple-type infection in Shenyang were 16, 52 and 58, the validity of presentvaccines is not good enough for cervical cancer prevention in local area.2. Sexual behavior is the mainly effective factor of HPV infection in local women.3. Among the screening methods we used, coloscopy or liquid-based cytologycombined with coloscopy are better.4. In our study the drugs intervening to HPV infections is no significant.