Biological Effects Of Platelet-Derived Growth Factor On The Cells Of Pulp And Periodontium

The platelet-derived growth factor ( PDGF) is well characterized peptide which is known to function in the regulation of mesenchymal cell proliferation. The initial in vitro studies of PDGF clearly demonstrated its mitogenicity for numerous cells of mesenchymal origin and its stimulation of the synthesis of matrix proteins. The ability of the factor to act synergistically has been supported by data showing that proliferation of mesenchymal cells occurred when they were exposed to the factor. The suggested role for PDGF as mediator of wound healing has been subjected to in vivo evaluations which repeatedly demonstrate the ability of PDGF, to enhance wound strength, connective tissue matrix density, synthesis of matrix proteins, and migration of macrophages and fibroblasts into the healing wound. Recent studies also indicated that PDGF might involved in the cellular activities of pulpal and periodontal cells, and might play an important role in periodontal tissue wound healing. thus the present studies were designed to investigate...