The Experimental Replacement Of A Esophageal Segment With Resorble Porcine Thoracic Aortas Acellular Matrix

Background: The current therapy for the diseased esophagus is by excision and replacement of the diseased esophagus by used of autografts of viscous such as the stomach, the colon and the jejunal loops. Artificial materials used to reconstruct esophagus in situ carry much scientific significance and practical value. Artificial esophagus can minimize invasive surgery, simplify the operation and uninfluenced the digestant function. It had been over 50 years of the research of artificial esophagus since Dr Berman firstly reported the experimental replacement of a segmental esophagus by use of polyethylene in 1951. Macromolecule materials such as silicone rubber, teflon, carbon fiber et al had been made into artificial esophagus in the past researches. Because of the bad tissue biocompatibility, esophageal epithelial and native esophageal structures can not be regenerated completely, they were associated with serious complications, such as infection, anastomotic leakage, stenosis and dislocation of the artificial esophagus. In recent years, with the development of biomaterials and biomedical engineering, artificial esophagus comes to reality. It is founded that natural extra cellular matrix, as the foundation of cell growth, was an ideal material for artificial organs. Compared to other composed materials, ECM (extra cellular matrix) have special biological activities which seldom cause the immuno-exclusive reaction, good biocompatibility and biodegradability which can apparently promote and induce the regeneration and repair of the tissue structure by appropriate modification and compound. The artificial substitute with structure and property similar to the body's can be used to repair, replacement of the tissue and...