| Several lines of experimental and clinical evidence suggest that autoimmune mechanisms are being implicated in an increasing number of diseases of nervous system. Many neurologists as well as immuno-logists are fascinated by such three questions:1)against what anti-gen(s) of the nervous system is the autoimmune response directed? 2) What is the mechanism of immune damage? and 3) What initiates or triggers the autoimmune response? During last decade great progress has been made in the researches of humoral and cellular immunity of patients with multiple sclerosis(MS), Guillain-Barre Syndrome(GBS), myasthenia gravis (MG), etc., including identification of major encephalitogens, detection of specific antibodies against myelin components,establishment of specific autoreactive T cell line/clone from MS patient. Neuroimmunology is just being started in China. Beginging in 1984,we have established several methods to measure five classes of immunoglobulin and albumin and detect specific antigen/antibody in CSF which enable us to further study : 1) Intra-thecal synthesis rate of five classes of Ig in neurological patients, 2)Detection of specific anti-MBP(Myelin Basic protein), anti-ganglio-side and anti-cerebroside antibody.3)measurement of MBP level in CSF/ serum of neurological patients.The results of our research are summerized as following;I. Intrathecal Synthesis of Five Classes of Ig and Its ClinicalSignificance Analysis First, we have established a rocket immunoelectrophoresis technigue... |
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