A Retrospective Clinical Analysis Of 388 Cases With Psoriasis

The pathogenesis of psoriasis is still unclear, however, it is recognized that psoriasis is closely associated with genetics and enviromental factors. This article is aimed to disclose some clues of the development of psoriasis and make a suggestion of more reasonable protocols of prevention and therapy by collecting and analyzing 388 patients' history with psoriasis and 87 patients with severe psoriasis who were admitted in our hospital during last ten years. More over 50 parametes are designed to meet the demand, including past history, laboratory examination and therapy effects by different protocols. All available datas are dealt with by statistical analysis. It was demonstrated that the age of onset was 20 to 40 years old , the average age of onset was 32 years old, no difference between males and females, which is coincided with traditional epidemiology. Getting cold is becoming the primary exacerbating cause, which lead patients to hospital admission. Laboratory examination found no definite relationship between psoriasis and internal disorders. Patients with liver dysfuncion or fatty liver occupy a little higher ratio in our data, however, which have no correlation with psoriasis but with advancing age and retinoids taking. From our retrospective study, we draw a conclusion that the emphasis of prevention and treatment of psoriasis should be put on to educate patients and avoid getting cold . The goal of theapy is not to effect a radical cure but ameliorate this disorders. The combination between Traditional Chinese Medicine and Western Medicine and topical therapy with gentle agents are the first choice to improve the patients with psoriasis vulgaris. As for the drugs to control severe psoriasis, retinoids are usually prescribed to patients with psoriasis erythroderma or pustulosa. They can improve the skin lesion but can't lessen joint pain on patients with psoriatic arthritis, which is the same as an immunosupuressant of cyclosporin A. Glucocorticosteroids can be sometimes used in treating patients with psoriasis erythroderma or psoriasis pustulosa, especailly those patients with no effects of other agents, and they should be withdrawn as soon as possible. NSAIDs are the firstchoice to treat patients with psoriatic arthritis, but indomethacin should not be choosed as it might aggravate the skin lesion. LeiGongTeng and methotrexate have an optimal effects to control joint symptoms of patients with psoriatic arthritis but should monitor the blood routine and hepatic function. Cyclophosphamide can also be administered but not the first choice.