Clinicopathological Research Of Jugulotympanic Paraganglioma With Analysis Of Prognostic Factors

Objects To observe pathological changes and expressions of vascular endothelial growth factor(VEGF),estrogen receptor(ER), progesterone receptor(PR),and androgen receptor(AR) in jugolotympanic paragangliomas and discuss prognostic factors in jugulotympanic paragangliomas. Subjects and Methods Clinical materials from 33 cases of jugulotympanic paragangliomas were obtained retrospectively. 17 archival specimens from the patiens were investigated using hematoxylin and eosin (HE) and immunohistochemical staining. The clinical materials and immunohistochemical results were analyzed using a statistical software -SPSS 10.0 for Windows. Results Each of 17 archival specimens contained rich blood capillaries and sinosoid. One of them invaded bone around the tumor. VEGF was expressed in 11 of them and correlated with Fisch classification positively(r=0.529,p<0.05). None of them expressed ER, PR or AR. It was suggested by Logistic regression that Fisch classification influenced on whether the tumor was left over or not significantly. The higher the Fisch classification, the more likely the tumor remained. Conclusions Jugulotympanic paragangliomas contains a lot of blood capillaries and sinosoid . Some of them have invasion. VEGF is expressed in jugulotympanic paragangliomas and may accelerate growth of them. The ER, PR and AR expressions are not found in jugulotympanic paragangliomas. Fisch classification is a indepentant prognostic factor in jugulotympanic paragangliomas.