| This subject is based on the theory of Tradition Chinese Medicine -Kidney tonify the marrou and hasten the brain. According to the function of prepared Rehmannia Root(Chinese name: Shu Di Huang) and the use in the Complex prescriptions of treating the dementia, We realized that Shu Di Huang has the function of tonifying the brain and the marrow, improving the partial or total loss of memory in clinic. We generalize these functions as "Improving Intelligence Function". So we use the methods of pharmacology to prove that Shu Di Huang has the function of improving intelligence and to show the mechanism.We used mice and Rats to do the experiments. The models were: 1. The memory process of acquisition impaired animal model made by Scopolamine. 2. The memory process of retrieval impaired animal model made by alcohol. 3. The dementia animal model made by A1C13. 4. The dementia of the Kidney-Yin animal model made by Monosodium Glutamate(MSG). The detected medicine was Shu Di Huang, the positive contrast medicine were Piracetam tablet and Liu Wei Di huang Decoction. We observed the influence of Shu Di Huang on the behavior of leanring and memory and we detected the the related neuroendocrine factors.The results were:1 .Effects of Shu Di Huang on the memory process of acquisition impaired of mice by Scopolamine.Shu Di Huang could improve the memory process of acquisition impaired cause by Scopolanine on mice. In Ssep down test, Shu Di Huang made the mice reduce the mistakes and prolong the incubation period(p<0.05),decreased the activity of acetylcholinesterase (AchE) (p<0.01), it can be compared with Piracetam group(p>0.05).2.Effects of Shu Di Huang on the memory process of retrieval impaired of mice by alcohol.Shu Di Huang could improve the memory process of retrieval impaired caused by forty percent alcohol on mice significantly. In step down tests, Shu Di Huagn made the mice reduce the times of mistakes(p<0.01) and prolong the incubation period (p<0.01,p<0.05),it can be compared with Piracetam group(p>0.05).3.Effects of Shu Di Huang on the dementia model animal caused by A1C13Shu Di Huang could significantly improve the learning ability of the dementia model mice. In step down tests the times of mistakes lowed(pO.Ol), the incubation period prolonged(p<0.05). In Morris water maze tests, Shu Di Huang made the model mice shorten the incubation period of seeking the platform(p<0.05). At the same time, Shu Di Huang decreased the content of Al3+in the brain of the dementia model mice(pO.Ol), and decreased the activityof AchE(p<0.05), decreased the level of Glutamic acid(Glu) and increased the level of Y -Aminobatyric acid(GABA) in mice brain greatly(p<0.01,p<0.05). There is no significant difference among Shu Di Huagn groups and Piracentan group(P.O>05).4.Effects of Shu Di Huang on the deficiency of the kidney-yin rants caused by MSG.Shu Di Huang could improved the function of learning and memory disturbance of rats caused by MSG greatly. In step down tests, Shu Di Huang could decrease the times of mistakes and prolong the incubation period(p<0.05). In Morris water maze tests, Shu Di Huang made the model animals shorten the incubation period of seeking the platform, and improved the rate percent through the platform position(p<0.05).At the same time, Shu Di Huang decreased both the level of cortisol(CORT) in the plasma(p<0.05) and expression of mRNA of glucocorticoid receptor(GRmRNA) in hippocampus; increased both the content of Glu in brain and the expression of hippocampal NMDAR1 ,GABAR, nerve growth factor(NGF), c-fos gene (p<0.05,P,0.01). Nissl body staining showed that hippocampal neurn nissl body granule is richful and the appearance is normal.In a word, (1) Shu Di Huang has the function of improving intelligence. The mechanism that Shu Di Huang improve the process of memory impaired caused by Chemical substance has relation with the decrease of the activity of AchE and the content Glu in brain, and is related to the increase of the content of GABA. (2) The effects of Shu Di Huang o...
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