The Influence Of Electro-Acupuncture On Diabetic Cognitive Dysfunction And Its Neurobioloical Mechanism

Diabetic cognitive dysfunction, which is an important causative factor of dementia, s a kind of clinical syndrome caused by the damage of diabetes to central nerve system and manifested by decreased memory, impaired attention, inflexible thought and decreased generalization capacity. Along with the medical model transforming from biomedicine into bio-psyco-social medicine, people all over the world come to pay great attention to the perniciousness of the diabetic cognitive dysfunction gradually. it is important to prevent and treat diabetic cognitive dysfunction for the forthcoming aging society. The following three aspects were concerned in this paper for the completely new area in TCM. I Literature research On the one hand, on review of the etiology and pathogenesis, treatment selection on syndrome differentiation of diabetes mellitus and cognitive dysfunction in 1CM, the author pointed out that tl~re were a few literatures relative to diabetes with cognitive dysfunction, such as General Collection for Holy Relief (Sheng Ji Zong Lv) and Trealys on Febrile diseases (Shang Han Lun) while none of them was specialized in diabetic cognitive dysfunction which can be divided into initiate, middle, and final stage in my opinion. For the detail, the initiate stage was mainly caused by Qi and Yin deficiency, disharmonious meridian leading to malnutrition of the brain; the middle stage was generated by stagnation of phlegm and blood stasis, Yang damage after Yin consumption leading to dysfunction of mental activity; the final stage was produced by complete deficiency of Qi, blood, Yin and Yang, stagnation of phlegm, dampness and blood stasis. It is closely related to brain and five Zang organs, especially heart, liver, spleen and kidney. Acu-bustion has a desirable effect on diabetic peripheral neuropathy and dementia. In addition, my directors have got a great experience on the treatment and research of dementia. On the other hand, on reviewing the knowledge of diabetes mellitus, cognitive dysfunction, animal model of diabetes and dementia in western medicine. The author pointed out that there was closely related between diabetes and dementia. Diabetic cognitive dysfunction played important role in dementia, which did great harm to human being. It was thought that degenerative nervous transmitter, hyperactive poiyol metabolism, increased free radical and decreased cerebral blood circulation generated diabetic cognitive dysfunction. As far as its treatment was concerned, at present, it still stayed at the trial stage. 2 Clinical study 45 cases of diabetic cognitive dysfunction were divided randomly into treatment group (n=25) and control group (n=20). Treatment group was treated by Electro-Acupuncture 30 miii every other day for 6 weeks while control group was dealt with Nimoton 30 mg three times a day. Blood glucose of both groups are under the control of western medicine for high blood glucose such as insulin. HDS, QOL, WMS, main symptoms scale were used to evaluate the cognitive function, quality of life, memory ability and the general condition of the patient, futhermore, fasting blood glucose was investigated before and after treatment. The results showed that : (DThere was significant difference between treatment group and control group. The therapeutic effect of treatment group was much better than that of control group P<0.00l ;㏕he main symptoms...