Study On The Clinical And Mechanism Of Inheriting Heart Psychotherapy And Treating Heart Stroke With

The objective:Summary of master Surongzhab Ce academic thought and clinical experience; observation of interaction between professor Surungzhab’s Mongolian medicine treatment and mind-body interactive therapy in the treatment of coronary heart disease, and to explore the mechanism of therapy.Methods and Material:1. Study of literature and reviewed master Surungzhab teenager life experience, youth school years of entrepreneurial experience, and the origins of Surungzhab’s academic thought and clinical contribution. While from his life experiences and who he become to understand how he grow to a Master.2. In guidance of Surungzhab professor, I read enormous papers, books and studied clinic medical records and other related Mongolian medicine classic treatments, by learn and study on method, selected ten best treatment disease, studied cause, symptoms, and treatment, from each disease select two typical cases to summary unique opinion of clinical experience. Retrospectively study of 190 patients with coronary heart disease who treated by Surungzhab, analysis of the effective and its frequency, thus further concluded his academic thoughts and clinical experience.3. On clinical study, we take 90 patients with coronary heart disease, according to the method of random divided into three group:1).Mongolian medicine group 30 patients treated by Surongzhab.2). Mongolian medicine combined with Mind-body interactive therapy 30 patients; 3). Chinese medicine (Dan Shen Di Wan) group:30 patients. Therapy goes on for 21 days.4. We took 6 patients blood sample at before and after treatment and 6 health people,10ml for each time, separate serum and save in -80 ℃, extraction of total RNA (total RNA), serum Hy3TM marking method is used to inspect the quality of total RNA, Microray technology tests for qualified RNA, contrast before and after treatment serum microrRNA changes, and compare before treatment patients with healthy people serum microRNAs, study the expression of microRNAs changes more than 2 times before treatment and normal people, explore the curative mechanism.Result:1. Surungzhab’s most prominent academic thought lies in the view of Mongolian medicine comprehensive understanding and excellent clinical practice. Professor Surungzhab had make first speech on 1980 and had published in 1983 about thinking of holistic Mongolian medicine this is the earliest research in the field of modern Mongolian medicine. He put forward "the view on the basis of the theory of Yin and Yang of Mongolian medicine. More specifically, he put out the correlation of man and nature, the correlation between three root and five elements, the correlation of three root and seven factors and three dirty, in which especially important relationship is three root and voxel dependent ’fine bad metabolism theory", these had enriched and developed the holistic theory for modern Mongolian medicine.In addition, Surungzhab teacher’s academic thought is embodied in:typical with roots cure as the fundamental; main is to treat the Hii; In order to promote blood circulating, dredge meridians and collaterals; Mediation between stomach fire and voxel balance; the removal of extra heat from body; Pay attention to psychological effect; Heart-body-word three combination; Emphasis on a total of nine aspects, such as health and fitness.According to the advice of a mentor and surveying the medical theory, heir the view of construction of Mongolian medicine summarized as below:"the body is a whole unity, body and mind are a whole unity, man and society, nature, universe (time and space) are related", and further Mongolian medicine model should be:"biological-psychological-social-natural-space-time (the universe)" composed ideas of five-dimensional structure.2. Through the analysis of diagnosis of Surungzhab teacher and pick 20 cases from ten disease such as:arrhythmia, myocardial infarction, kidney stones, chronic bronchitis, chronic gastritis, insomnia, psychiatry disease, epilepsy, menoxenia, uterine fibroids, studied the concept, etiology, symptoms, treatment, and summarized Surungzhab teacher’s unique insights and diagnosis technique, and found that Surongzhab teacher integrated use of four principle, flexible on medicine use, including ingredient added to the medicinal herbs, showed dialectical thought all over treatment.From all these treatments for coronary heart disease had outstandingly effective. The result of retrospective analysis of Surungzhab teacher diagnosed and treated 190 patients with coronary heart disease:(1)The cause of the coronary artery occlusion was fine bad metabolism, muddy thing gelling in blood vessel walls; The disease diagnose as element combination type Hii(vital energy) and blood disorder.(2) The treatment is promote fine bad metabolism function, dredge the meridians, improve vital spirit and blood running, according to dialectical thought treat specific illness.(3) Details of Mongolian medicine:Morning:the Jiruhun shimjil,10 grain, Hododun-10,5 grain Afternoon:new-II,13 grain, Zandan-3,1.5 grams, Yehe Tang-25,1.5 grams; Night:Erdni Urul,15 grain, Aarul-35,3 grams.(4) The top five drug use:Erdeni urul, Agaaru-35, Yeh tang, Jiruhun shimjil, new-Ⅱ; Use frequency respectively:100%,100%,95.3%,89.5%,68.9%,57.9%.(5) The prescription for combined symptom:for insomnia use Sugmel-4 soup, when the stomach bilges use Mordabvs-4 soup, when showed heart palpitations use shusha-7 or Amin Erdeni,when combined with caughing use Cher-11 or SaChu-3 flavour, when rheumatism ache symptom use Zanden-4 soup, Chagaangugul-10 flavour or Zanden-11 flavor powder, etc.(6) Direction for cultivate diet and mental health:such as appropriate digestible diet, avoid greasy food; avoid excessive overwork, stay out of noisy environment, appropriate physical exercise. Avoid angry and sad, encouraged to participate cheerful event, etc.(7)The average period of treatment:27.18+/-22.89 daysConclude above, Surongzhab’s treatment on coronary heart disease is concentrate on helping mediate stomach fire, promote to remote the poison and emphasize on both of Hii and blood problems, for these use the Jiruhun shimjil and new-II which are new medicine invented by him and showed great curative on clinic. Therefore I combined Mongolian medicine mind-body interactive therapy with his Mongolian medicine treatment received great curative on coronary heart disease.3. The result showed the symptoms of three groups improved significantly after treatment (P< 0.05),Compared between three treatment, Mongolian medicine group of dry mouth, flustered symptoms improved significant than observation group, observation group chest distress symptoms improved significant than Mongolian group, the above two groups were better than the-control group; but is no difference between three groups (P> 0.05); Electrocardiogram was no significant difference between observation group and control group (P> 0.05); The clinical total effective observation group, the Mongolian medicine group and control group are 86.7%,80.0%,76.7%, Group psychological treatment curative effect is superior than the Mongolian group and the control group, but no significant difference between groups (P> 0.05).4. Microarray technology testing results show that the contrast before and after treatment serum microRNA expression changes more than 2 times (P<0.05) have 34; Compared before treatment and normal health people’s serum microRNAs expression, changes more than 2 times (P< 0.05) have 19; Change more than 2 times in three groups of microRNA had7. From these seven microRNAs we found well studied Has-miR-766-3P. This microRNA related to FLT4 and ADAM9 genes which are associated with coronary heart disease. Tyrosine-protein kinase (FLT4) is acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. And study showed VEGF had related to severity of coronary heart disease. ADAM9 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and had related to atherosclerosis. But still need further study to understand potential function of Has-miR-766-3P in Mongolian Mind-body therapy combined with Surungzhab’s Mongolian medicine treatment of coronary heart disease.Conclusion:① National physician, master professor Surungzhab makes great contribution on Mongolian medicine integrate ideas and theories, the guidance of clinical work has significance practical value; Surungzhab teacher had substantial clinical experience, and has its own unique thinking and diagnosis and treatment technology in which key is treatment on Hii, promoting Hii and blood circulation, mediate stomach fire, eliminate the extra heat inside of body, emphasize psychology, associate mind-body-talk together and nourshing of life to change the health care system, this part might accordance with modern medical model. Therefore thoughts of master Surungzhab contribute highly valuable in medical work.② Professor Surungzhab had his own medical thoughts and success in medical outcome. Most famous work is on diagnosis and treatment of coronary heart disease, first of all will use Jiruhun shimjil and new-II, and the curative rate had proved from clinical and reference, treatment begin from find the roots source, emphasize to cure stomach fire, promote the metabolism and adjust Hii(vital spirit) and blood function, pay attention to mental health.③ On the basis of Surungzhab’s experience prescriptions combined with mind-body interactive therapy improved significantly for coronary heart disease patients.④ We studied serum microRNAs expression to detect probably mechanism, and found out Has-miR-766-3P might related to mechanism of Mongolian Mind-body therapy combined with Surungzhab’s Mongolian medicine on coronary heart disease.