| Objective(1) In combination with modern clinical research methods as the basis, using optimized instrument of Mongolian medical brain treatment, we have clinical study of Mongolian medical brain treatment of migraine, thereby expanding the Mongolian medical brain indication range.(2)By clinical study of Mongolian medical brain treatment of migraine, we strived to provide a simple model of Mongolian medicine appropriate technology, providing the scientific basis for the modernization of Mongolian medicine.MethodsThe 90 cases of patients who met the inclusion criteria were randomly divided into theree groups, which were the treatment group (30 cases),control groupl (30 cases)and control group2 (30 cases).The treatment group used Mongolian medical Brain Vibration Treatment, the control group1 used Acupuncture treatment,and the control group2 used massage therapy. Those groups were treated for four weeks.1. Score changes of headache and the total therapeutic effect before and after treatment were observed and compared between three groups of clinical symptom.2. The changes of the three groups’s TCD index and the indexes of blood rheology were observed and comparedbefore and after treatment,Mongolian medical brain therapy on migraine patients with TCD index and the indexes of blood rheology effects were analyze.3.5-serotonin, nitricoxide(NO), plasma endothelin(ET) contents of three groups were observed and compared before and after treatment, The possible mechanism of Mongolian medical brain therapy in the treatment of migraine from the biochemical factors was preliminary analysed, in order to make a foundation for the follow-up study.Result1. Clinical curative effect comparison before and after treatment1.1 Pain scores comparison before and after treatment in three groupsThe pain score difference of three groups before treatment was not statistically significant P>0.05, comparable After treatment headache severity score of three groups of patients were significantly decreased to before treatment, P<0.05.There was no significant difference between the treatment group and the control group 1 after treatment, P>0.05. There was significant difference between the treatment group and the control group 2after treatment, P<0.05.1.2 The headache attack frequency comparison of three groups before and after treatmentThe pain score difference of three groups before treatment was not statistically significant P>0.05, comparable. The headache severity score of three groups of patients after treatment were significantly decreased, P<0.05. There was no significant difference between the treatment group and the control group 1 wasafter treatment, P>0.05, There was significant difference between the treatment group and the control group 2, after treatment, P<0.05.1.3 The headache duration comparison of three groups before and after treatmentThe headache duration of three groups before treatmenthad no significant difference P>0.05, comparable The headache duration of three groups of patients after treatment was decreased significantly, P<0.05. There was no significant difference between the treatment group and the control group 1 after treatment, P>0.05.There was significant difference between the treatment group and the control group 2 after treatment, P<0.05.1.4 The headache with symptoms comparison of three groups before and after treatmentThe headache symptoms of three groups before treatment had no significant difference P>0.05, comparable. The symptoms of headache of three groups patients after treatment was significantly decreased P<0.05. There were no significant difference between the treatment group and the control group 1 or the treatment group and the control group 2 after treatment, P>0.05.1.5 VAS score comparison of three groups before and after treatmentThe VAS score of three groups before treatment had no significant difference P>0.05, comparable. After treatment, VAS score of three groups were significantly decreased P<0.05. There was no significant difference between the treatment group and the control group 1 after treatment, P>0.05.There was significant difference between the treatment group and the control group 2 after treatment, P<0.05.1.6 Clinical curative effect comparisonThere was no significant difference in the clinical curative effect between the treatment group compared and the control group 1, P>0.05.There was significant difference between the treatment group and the control group 2, P<0.05. 2. TCD indexthree groups after the treatment, the mean blood flow velocity of TCD, MCA, PCA ACA index, VA and BA (Vm) were significantly improved, and compared with group before and after treatment of P<0.05 or P<0.01 (After the treatment, the mean values of all the three groups’ blood flow velocity of TCD indexes, which concludes ACA, MCA, PCA, VA and BA are all improved markedly, difference statistically significant in each group before and after treatment (P<0.05/P<0.01); the difference between treatment group and the two control groups. was statistically significant. The curative effect of the treatment group was better than that of the control group 1 and control group 2.3. The changes of blood rheology indexeschanges of blood rheology indexes were significantly improved in each of the three groups, difference statistically significant before and after the treatment (P<0.05), (indicating that all the three treatments can markedly improve blood rheology of patients with migraine); the difference between the treatment group and the two control groups after treatment was not statistically significant P>0.05), (indicating that the effect in improving blood rheology of the three methods to treatment migraine is close.)4. The changes of 5-HT contentthe content of plasma 5-HT was significantly improved, difference statistically significant in each group compared with before-treatment.(P<0.05) indicating all the three treatments can improve content of plasma 5-serotonin significantly in patients with migraine c; the treatment group compared with the control group 1 after treatment, difference is not statistically significant(P>0.05), while compared with the control group 2 w difference statistically significant (P<0.05). It shows that the effect for the plasma 5-serotonin is close between the treatment group and control group 1, both better than control group 2.5. The content changes of plasma endothelin (ET) and nitric oxide (NO)The three groups after treatment, the plasma endothelin (ET) and nitric oxide (NO) content were significantly improved andin one group there was significant differences between before and after treatment P< 0.05, indicating the three groups of treatment on patients with migraine significantly improved endothelin (ET) and nitric oxide (NO) content. There was no significant difference between the treatment group and the control group 1 after treatment, P>0.05. There was significant difference between the treatment group and control group 2 after treatment, P<0.05. Mongolian medical brain treatment on patients with migraine endothelin (ET) and nitric oxide (NO) content is comparable to the effect of acupuncture,and is better than that of traditional Mongolian medicinemassage therapy.Conclusion1. Mongolian medical brain treatmentis an effective treatment for migraine, which the effect is close to that of the Chinese medicine acupuncture treatment and is better than that of traditional Mongolian massage therapy.2. Mongolian medical brain treatment improved the migraine TCD and blood rheology, serum 5-HT, NO, ET and other biochemical indexes significantly.3. The curative effect of Mongolian medical brain treatment to treat migraine is distinct, and the operation is simple, non-invasive, safe, non-toxic side effects. |
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