Analysis And Research On The Clinical Literature Of Banxia Aconitum Anti - Drug Combination From The Perspective Of Evidence - Based Medicine

Eighteen incompatible herbs is the synonymous with traditional Chinese medicine incompatibility. From Jin and Yuan Dynasties to today, it has almost a thousand years of history. The theory of Eighteen incompatible herbs has Limited on the clinical application of anti-drug, but ancient and modern times has some clinical application to cure some difficult and complicated diseases. So anti-drug whether can be used in the clinic, ancient physicians have different points of view, someone thinks using the anti-drug could increase toxicity and reduce the efficacy; someone thinks using the anti-drug could produce mutual stimulation to cure incurable diseases. So anti-drug whether can be used in clinic is a burning question in the medical field.We all know Chinese medicine theory derived from the clinical, using the clinical applications as the guiding principles, so the eighteen incompatible herbs is a clinic question in final analysis. Although many recent theoretical and experimental study of initial eighteen incompatible herbs is the incompatibility under certain conditions, rather than the absolute incompatibility, but there are certain conditions such uncertainties, we can not rush to conduct clinical trials in the crowd otherwise, it would be contrary to the harm principle in medical ethics. Consequently in the crowd at this stage to carry out the eighteen incompatible herbs conditions for application of clinical trials there is a certain degree of difficulty, not easy to be pursued. So we try to use Evidence-Based Medicine approach to evaluate eighteen incompatible herbs’s clinical application, from the perspective of modern clinical research literature to reveal the clinical applications of eighteen incompatible herbs.Evidence-Based Medicine is a new discipline of clinical medicine developed rapidly in recent years, which has become the new direction of development of international medical research. Evidence-Based Medicine methods which used to evaluate the efficacy and safety of interventions have been generally accepted by the World Health Organization (WHO) and the various countries. [Objective]The topics will systematically accessed on the basis of "banxiawutou"class of the eighteen incompatible herbs, then research the type of clinical research of "banxiawutou" class of anti-drug compatibility of combinations to carry out Evidence-Based Medicine evaluation studies.[Method]1, Documentation Systems Retrieval2, Access Database creation3, Statistical description and analysis4, EBM’s systematic review and Meta-analysis method[Contents]1, From the perspective of Evidence-Based Medicine to launch systematic reviews toward eighteen incompatible herbs with "banxiawutou" class anti-drug compatibility combination therapy clinical research safety of the systematic review2, From the perspective of Evidence-Based Medicine to launch systematic review toward eighteen incompatible herbs with "banxiawutou" class anti-drug compatibility combination therapy clinical efficacy3, Analyzing the research literature characteristic of the compatibility of antidrug combination of clinical study types and clinical applications of "banxiawutou" class of eighteen incompatible herbs[Result]1, Documentation Systems Search ResultsSearching the clinical application literature totals up to 3806 pieces.2569 pieces are "banxia" and "wutou"using in "tongfang",1237 pieces are "banxia’ and "wutou "using in "jiajianfang". In the 3806 pieces documents,1623 pieces are case report,358 pieces are case series.304 pieces are expertise,238 pieces are randomized controlled trials,6 pieces are non-randomized controlled trials.2, Database resultsWe establish two sets nine databases:RCT database, CCT databsse, CR database, CS database and EX database and RCT-jiajian database, CCT- jiajian databsse, CS- jiajian database and EX- jiajian database. The content of the databases contains documents’basic information:the basic information of document, pathogenetic conditions’information, therapeutic effect, situation of anti-drug and the data’s extraction.3, Compatibility of anti-drug combination of safety evaluation and studyThe banxia and wutou with the use of literature,52 pieces account the herbs can be used together. Among them,11 pieces pointed out that they can use effectively and safely; 18 pieces pointed out that they can use safely.12 pieces pointed out that they can use effectively.4, Compatibility of anti-drug combination of efficacy evaluation resultsBecause the conditions which to lanch the meta-analysis were unable to meet, so we can’t conducted the systematic review from Evidence-based medicine angle.5, Document Characteristic Analysis5.1 Anti-drug use treatment of diseasesThe banxia and wutou clinically use together mainly to cure the medicial diseases. Such as "bizheng" (chronic arthritis), "chuunzheng" (chronic bronchitis or asthma), "xinji" (coronary heart disease or angina). "weiwantong"(Chronic gastritis),etc.5,2 Cooked up by the anti-drug compatibility with the use of clinical drug useThe banxia is always to be used in "fabanxia". "wutou" is always to be used in "zhiheifupian"."chuanwu" and "caowu"always used togher with "banxia" in "shengchuanwu " and "shengcaowu "5,3 Anti-drug compatibility with the clinical doseThe banxia is always to be used in "fabanxia" with the dose of "10g", "wutou" is always to be used in "zhiheifupian" with the dose of "10g" "chuanwu" and "caowu"always used togher with "banxia" with the dose of "30g" or"10g".5,4 Anti-drug compatibility with the use of ratioThe banxia and wutou often compatibility use the ratio of 1:1 regardless of one or several forms of "wutou" using together.5,5 the anti- drug compatibility with the clinical drug formulations and routes of administrationThe banxia and wutou on the clinical use often made "soup" within the oral form.5,6 the conditions of specific drug usageThe banxia and wutou often compatibility use with the "buxuyao", then the "jiebiaoyao", "huoxuehuayuyao ", "lishuishenshiyao ", "huatanzhikepingchuanyao",etc. The specific drug is "gancao", "baizhu’ "dangshen", "huangqi", "guizhi", "xixin", "fuling", etc.5,7 documented anti- drug quality evaluation of the clinical literatureFrom the published literature of the unit, the quality of journals, published the era of tripartite face of literature quality evaluation shows that the quality of the literature we retrieved or high.[conclusion]1, From types of clinical research, the CR and CS documented the most, followed by the RCT and CCT literature.2, From the anti- drug use, both in terms of clinical safety and efficacy, we know, in clinical, Anti-drug compatibility portfolio in the clinical application is a certain basis, it is feasible and effective. Clinical anti-drug use, but need to be carried out "under certain conditions, a certain range, such as "fabanxia" with "zhiheifupian", each "10g"are made "soup", "oral".3, Improve the quality of the article, especially the safety’s description to raise people’s safety awareness.4, After finishing the analysis of literature found that the existing published eightteen anti- literature, and even Chinese medicine literature in the field of literature quality to be improved in many respects is not precise enough and need further improvement. Such as Chinese medicine medicine concocted medicine adverse reactions after treatment, the treatment of diseases, disease name standardization situation, some articles did not explicitly mention or non-standard positioning, so many of the problems difficult to trace. For certain drugs, further research is very unfavorable from the perspective of evidence-based medicine, it is recommended that future researchers to rigorous attitude to quality literature.