A Meta-analysis Of The Correlation Between Abnormal Vaginal Microecology And High-risk HPV Infection

Objective:To systematically evaluate the association between abnormal vaginal microecology and High Risk Human Papilloma Virus(HR-HPV)infection to provide evidence-based clinical evidence.Method:By using advanced computer search technology,we can access the latest published Chinese and English literature and journals from many databases such as Wanfang,Zhiwang,Wipu,Ovid-Medline,Pubmed,Embase,and collect valuable information until December 2022.To conduct a comprehensive search for studies on the association between abnormal vaginal microecology and high-risk HPV infection.A rigorous screening of the literature was conducted independently by 2researchers to include literature that met the criteria of this study.They were divided into a group positive for high-risk HPV infection and a group free of HPV infection,and the association between the two groups was observed for Aerobic vaginitis,Bacterial vaginosis,Vulvovaginal Candidiasis,Trichomonas vaginitis Trichomonas Vaginitis),Chlamydia trachomatis,(Chlamydia trachomatis)Mycoplasma urealyticum,and Meta-analysis of the obtained data was performed using Stata 17.0software.Results:The results of the Meta-analysis suggested that AV was significantly associated with HR-HPV infection and AV infection was a risk factor for HR-HPV infection,with a combined Odds Ratio(OR)and95% Confidence There was a significant association between BV and HR-HPV infection,and BV infection was a risk factor for HR-HPV infection,with a combined OR and 95% CI of 2.76(2.42-3.15),P=0.000,a statistically significant difference.VVC was significantly associated with HR-HPV infection,and VVC infection was a risk factor for HR-HPV infection,with a combined OR and 95% CI of 1.43(1.09-1.88),P=0.010,a statistically significant difference.TV was significantly associated with HR-HPV infection,and TV infection was a risk factor for HR-HPV infection,with a combined OR and 95% CI of 1.33 CT was significantly associated with HR-HPV infection,and CT infection was a risk factor for HR-HPV infection,with a combined OR and 95% CI of4.34(3.05-6.19),P=0.000,a statistically significant difference.u U was statistically significantly associated with HR-HPV infection,with a combined OR and 95% CI of 4.34(3.05-6.19),P=0.000.-HPV infection was significantly associated,with a combined OR and 95% CI of 2.97(2.11-4.19),P=0.000,a statistically significant difference.Conclusion:1.AV,BV,VVC,TV,CT,and UU were significantly associated with HR-HPV infection;2.AV,BV,VVC,TV,CT,and UU patients were at higher risk of cervical HR-HPV infection.