Study Of High Resolution Swept Source Optical Coherence Tomography Angiography In Diabetes Retinopathy

Objective: Swept source optical coherence tomography angiography SS-OCTA was used to analyze and quantify the optic disk blood density of diabetic retinopathy(DR),so as to explore the early retinal blood flow density changes in diabetic patients and provide a certain basis for early retinal screening of diabetic patients.Methods: Using retrospective studies,66 diabetic patients and 116 eyes diagnosed in the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)from May 2021 to October 2021 were included for complete ophthalmic examination,and 20 eyes in the age-and sex-appropriate control group were included,and all experimental groups were divided into no retinopathy group(stage 0 group)and non-proliferative diabetic retinopathy.NPDR),proliferative diabetic retinopathy(PDR),experimental group and control group were corrected vision examination,dilated pupil examination fundus,wide-angle fundus photography,optical coherence tomography(OCT)and SS-OCTA examination,and superficial retinal blood flow density(Superficial)centered on the optic disc capillary plexuses(SCP),deep capillary plexus(DCP)and choriocapillaris(CC)were quantified,the changes of DR blood flow density were analyzed,and the different effects of related factors on DR were further analyzed..Results: 1.General data: the difference between the control group and the experimental group in ocular distinction,gender,age,intraocular pressure,triglycerides was not statistically significant(P>0.05);the difference between best corrected visual acuity(BCVA),glycated hemoglobin(Hb A1c)and cholesterol was statistically significant(P<0.05).There was a significant positive correlation between diabetes grouping and Hb A1 c and cholesterol.2.Superficial retinal blood flow density: statistically significant differences between PDR group and control group in the optic disc region and temporal side of SCP layer(Pc<0.05),statistically significant differences between NPDR group and PDR group compared with control group in the SCP layer above temporal and above temporal(Pb<0.05,Pc<0.05),and statistical differences in the SCP layer above the nose and nasal side: stage 0,NPDR group and PDR group compared with the control group were significant(Pa<0.05,Pb<0.05,Pc<0.05).3.Deep retinal blood flow density: In the DCP layer,the difference between the PDR group and the control group was statistically significant(P<0.05).4.Choroidal blood flow density: in the CC layer,the stage 0 group had a statistically significant P<0.05 above and below compared with the control group,and the NPDR group had a statistically significant P<0.05 compared with the control group.5.Correlation between severity of DR and mean retinal blood flow density: DR severity was positively correlated with deep mean blood flow density and negatively correlated with choroidal mean blood flow density;There was no significant correlation with superficial mean blood flow density.Conclusion: 1.The application of SS-OCTA examination can observe the early retinal blood flow density change in diabetic patients;2.We found that at different levels of the retina of diabetic patients,there are different degrees of blood flow density reduction;3.The application of SS-OCTA can be a useful tool for monitoring early retinopathy in diabetic patients in the future,but further research is still needed.