Tumor Treatment Studies Of Oxaliplatin Combined With Photodynamic Therapy To Enhance Immunogenic Cell Death

Cancer is the most incurable disease in the world today,and the treatment methods are limited.As a conventional treatment,chemotherapy plays an important role in cancer treatment.Among them,the use of platinum chemotherapy drugs accounts for more than half of the total clinical chemotherapy drugs.However,platinum drugs have defects such as large toxic side effects and drug resistance.Therefore,the improvement of platinum drugs and the research on new therapeutic mechanisms are particularly important,which are of great significance to human health.When using drugs or radiation to treat tumors,immunogenic cell death(ICD)is usually caused,so that tumor cells change from non-immunogenic or low-immunogenic to immunogenic,and finally stimulate anti-immunity in the body.Tumor immune response.The nuclear efflux of high mobility group box protein B1,the efflux of adenosine triphosphate and the efflux of calreticulin are the three hallmark processes of ICD.By detecting these three key molecules,it is possible to determine whether tumor cells have ICD.Photodynamic therapy(PDT)is a commonly used tumor treatment method,which can induce tumor cell apoptosis and ICD effect by generating reactive oxygen species(ROS),and has good spatiotemporal selectivity.Poison treatment.PDT has three elements,namely light,photosensitizer and oxygen.Currently,finding a suitable photosensitizer is a key research direction in the field of PDT.Based on the above two backgrounds,this paper uses oxaliplatin as raw material to synthesize the amphiphilic oxaliplatin polymer P1,and then use P1 to encapsulate the photosensitizer material chlorphene e6.Force self-assembles into a photodynamic polymer nanomaterial NP2 that can be targeted for delivery.The nanoparticle can generate photodynamic effect under near-infrared light irradiation,thereby enhancing oxaliplatin-induced tumor cell ICD effect,achieving photodynamic and chemotherapy.The role of drugs in synergistic treatment of tumors.Finally,it was proved by experiments that the combination of chemotherapeutic drugs and photodynamic therapy can promote each other,enhance the ICD effect,and induce tumor cell death.With the deepening of ICD effect and photodynamic therapy research,the direction of cancer treatment is likely to undergo some changes in the future.Traditional chemotherapy drugs are more likely to damage tumor cells or inhibit their growth and proliferation,and future research directions may be more inclined to Destroy tumor cells by enhancing the body’s immunity.