Preparation And Application Study Of Ti₃C₂T_x MXene Composites For Sweat Glucose Sensing

With the improvement of people’s living standards and the importance of their health,it is of great significance to quickly and accurately detect the content of glucose in body fluids.Electrochemical methods have the advantages of easy operation,low cost,rapid detection and high sensitivity,but the corresponding electrode materials still need continuous improvement in terms of the number of chemically active sites,electrocatalytic performance and stability.In this paper,three electrochemical sensing electrodes with excellent catalytic performance for glucose detection were constructed based on Ti₃C₂T_x MXene nanomaterials,compounded or doped with other materials with good electrocatalytic performance for glucose.The main studies are summarized as follows:（1）A three-dimensional porous Ti₃C₂T_x MXene/Graphene/Au NPs composite membrane was designed and constructed,and a good carrier for glucose oxidase immobilization was obtained.Through optimization,the glucose sensor showed a high sensitivity of 169.49μA/（m M?cm²）in the low glucose concentration range of 2μM～0.4 m M,the detection limit was 2μM,the response time was less than 3 s,and the stability and repeatability were high.The excellent electrochemical performance is attributed to the large specific surface area,high conductivity and stable porous structure of the 3D composite membrane.By using the composite membrane,the detection of glucose content in human sweat was realized.（2）Ti₃C₂T_x MXene/Cu-MOF composites were designed and prepared by growing Cu-MOF nanosheets in situ on the surface of monolayer Ti₃C₂T_x MXene.The material has excellent electrical conductivity,large specific surface area and abundant catalytic active sites for non-enzymatic glucose sensing.The glucose sensor achieved a high sensitivity of 688μA/（m M?cm²）in the glucose concentration range of 1μM～0.655m M,a detection limit of 0.047μM,a response time of less than 10 s,and good stability and reproducibility.（3）Ti₃C₂T_x MXene/Cu₂O/Cu O/Cu（OH）₂ composites were prepared by a one-stirring electrolytic method.The mixed valence copper ions accelerate the redox reaction of glucose by synergistic effect,and the abundant active sites on the organ-like MXene surface greatly increase the loading of Cu₂O/Cu O/Cu（OH）₂ nanoparticles.The glucose sensing electrode based on this composite exhibited ultra-wide linearity in the concentration range of 1μM～16.155 m M glucose.In addition,the glucose sensing electrode showed good selectivity and long-term stability,making it suitable for the detection and quantitative analysis of glucose in real samples.