Fabrication Of Prussian Blue Analogue Nanomaterials For Cancer Theranostics

Cancer is also known as malignant tumor,although the rapid development of modern medical level is improving rapidly,conquering cancer is still a thorny problem.The traditional cancer treatment strategies include chemotherapy,radiotherapy,and surgery,which can expose patients to severe side effects and unsatisfactory treatment outcomes.Fortunately,with the development of nanomaterials and nanotechnology,nanomedicine have emerged.New treatment methods have brought a new dawn for cancer patients,such as photothermal therapy,nanocatalytic therapy,chemodynamic therapy,etc.A single treatment can’t achieve the satisfaction of cancer patients due to the tumors and their tumor cell microenvironment are diverse.Therefore,the synergistic use of multiple treatment becomes a necessary trend.Multimodal tumor synergistic therapy produces a stronger therapeutic effect than single treatment.As a nano-biomimetic material,prussian blue analogues has an inestimable application prospect in the biomedical field.This paper mainly synthesizes composite nanomaterials based on Prussian blue analogues,which synergism chemical therapy,photothermal therapy and chemodynamic therapy,so as to achieve the purpose of synergistic treatment of tumor.The specific research contents are as follows:（1）This section successfully prepared PAA@Mn CO₃@Mn Fe-PBA NPs by the sacrificial template method and applied it to the combination treatment of tumors.PAA@Mn CO3@Mn Fe-PBA NPs exhibit an excellent property of continuous warming under near-infrared laser irradiation and p H/NIR responsive drug delivery property.Meanwhile,under the conditions of weakly acidic tumor,the frame of Mn Fe-PBA NPs.will collapse to continuously release Mn²⁺,improving the MRI capacity.While the Fenton-like reaction also occurs at the tumor site to produce a strong oxidative hydroxyl radical（·OH）.In addition,according to the synergistic therapeutic effect of PAA@Mn CO₃@Mn Fe-PBA NPs in human hepatoma cells（Hep G-2）,composite nanoparticles based on Prussian blue analogues have the potential for synergistic therapy of photothermal therapy,chemical therapy and chemodynamic therapy.（2）This section synthesized Mn Fe-PBA@PAA@PDA NPs by using a simple and gentle approach,which can improve the photothermal conversion efficiency to 45.3%due to dopant of Mn²⁺.At the same time,it has a high loading of hydrophobic drugs under the modification of cyclodextrin.Moreover,in vitro cell experiments showed that the nanoparticles have good biocompatibility safety.In addition,the Combined photothermal therapy and chemotherapy demonstrated effective treatment to Hep G-2 cells.The prepared Mn Fe-PBA@PAA@PDA NPs is expected to play an important role in the theranostics of cancer.