Accurate Synthesis Of Nanoscale Colloidal Molecules Spanning Biological Interfaces

With the development of nanomaterials in the biological field,the controllability of nanomaterials structure has attracted more and more attention.In the nanocomposites of various structures,colloidal molecular structure nanomaterials can not only simulate a variety of molecular structures in morphology and structure,but also facilitate the multifunctional combination in composition,so they have good structure design and functional regulation.With the rapid development of science and technology,the controllable preparation and performance of colloidal molecules has become a hot research topic.Bottle brush polymers,due to their unique structure,can form complex but highly ordered substances.Through the selection of macromonomer and the control of the polymer synthesis process,the synthetic size,shape and composition can be precisely designed.Based on this,this topic of the use of the bottle brush molecules as the middle segment,through the universal copolymer-micelle mediated strategy try to develop a new type of nano-scale colloidal molecules with precise configuration,throughout the process of synthesis shows a high degree of colloidal stability,makes at high particle concentration has extremely rich regulatory parameters.The experimental results are presented as follows:(1)The process of synthesizing bottle brush homopolymer by macromonomer containing a norborgene group through open-ring translocation polymerization(ROMP)is usually faced with the problems of intramolecular cross-linking caused by large monomer resistance and low monomer conversion rate.We have developed a new technology for the synthesis of high-quality bottle brush molecules,which effectively avoids the technical problems faced by ROMP by assembly before polymerization.Block polymers of polystyrene and tert-butyl polyacrylate in n-hexane,adjust the proportion of n-hexane in the solution,the polymer before and after assembly,and the kinetic monitoring,the experimental results show that the traditional polymerization in good solvents,reduce the reaction concentration of gel,the final conversion is only 9.44%,and the final conversion of assembled monomer can reach 98% and above,and the peak shape of the polymers is monodisperse.Therefore,the influence of the position resistance effect is effectively avoided,and the high-quality bottle brush molecules are obtained.synthesized from styrene and tert-butyl acrylate were used as homopolymeric macromolecules,and macroassembly and then polymerization were synthesized by adjusting solvent composition before polymerization,proving the methodological concept of "post-assembly polymerization".In this system,due to the different solubility(2)With bottle brush block polymer-block-poly(borene-graft-polystyrene)as the template,selective in situ growth of silica nanoparticles,successfully produced with silica nanometer particles as the "head",bottle brush block polymer for "tail" structure parameters of parental nanoscale colloidal molecules.When changing the solvent environment,the relative size of the "head" and "tail" affects their relative motility,making it show different assembly effects when assembled in a selective solvent.(3)The adjustable structure of the nanoscale colloidal molecules was realized through the intermediate bottle brush molecules,and the dumbbell-like colloidal molecules with the middle and gold nanoparticles were successfully prepared by the method of in situ growth.The synthesized colloidal molecules were tested for cytotoxicity,the colloidal molecules with polydimethylsiloxane and polyethylene glycol as intermediate segments at the concentration of 80 ug / m L were greater than that of ordinary gold nanoparticles.Thus,the structural features give the composite good stability,processability,and biocompatibility.